Cargando…

DNA copy number profiling reveals extensive genomic loss in hereditary BRCA1 and BRCA2 ovarian carcinomas

BACKGROUND: Few studies have attempted to characterise genomic changes occurring in hereditary epithelial ovarian carcinomas (EOCs) and inconsistent results have been obtained. Given the relevance of DNA copy number alterations in ovarian oncogenesis and growing clinical implications of the BRCA-gen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kamieniak, M M, Muñoz-Repeto, I, Rico, D, Osorio, A, Urioste, M, García-Donas, J, Hernando, S, Robles-Díaz, L, Ramón y Cajal, T, Cazorla, A, Sáez, R, García-Bueno, J M, Domingo, S, Borrego, S, Palacios, J, van de Wiel, M A, Ylstra, B, Benítez, J, García, M J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668473/ https://www.ncbi.nlm.nih.gov/pubmed/23558894 http://dx.doi.org/10.1038/bjc.2013.141

Ejemplares similares

Deletion at 6q24.2–26 predicts longer survival of high‐grade serous epithelial ovarian cancer patients
por: Kamieniak, Marta M., et al.
Publicado: (2014)

The NER-related gene GTF2H5 predicts survival in high-grade serous ovarian cancer patients
por: Gayarre, Javier, et al.
Publicado: (2016)

Prevalence of BRCA1 and BRCA2 Jewish mutations in Spanish breast cancer patients
por: Díez, O, et al.
Publicado: (1999)

Gene expression profiling integrated into network modelling reveals heterogeneity in the mechanisms of BRCA1 tumorigenesis
por: Fernández-Ramires, R, et al.
Publicado: (2009)

MicroRNA-based molecular classification of non-BRCA1/2 hereditary breast tumours
por: Tanic, M, et al.
Publicado: (2013)

Molecular analysis of the BRCA1 and BRCA2 genes in 32 breast and/or ovarian cancer Spanish families
por: Osorio, A, et al.
Publicado: (2000)

Molecular insights into the OGG1 gene, a cancer risk modifier in BRCA1 and BRCA2 mutations carriers
por: Benitez-Buelga, Carlos, et al.
Publicado: (2016)

Mutational analysis of BRCA1 and BRCA2 genes in Peruvian families with hereditary breast and ovarian cancer
por: Buleje, Jose, et al.
Publicado: (2017)

Hereditary and non-hereditary branches of family eligible for BRCA test: cancers in other sites
por: Digennaro, M., et al.
Publicado: (2017)

The role of BRCA1/2 in hereditary and familial breast and ovarian cancers
por: Hawsawi, Yousef M., et al.
Publicado: (2019)

Hereditary Susceptibility to Breast Cancer: Significance of Age of Onset in Family History and Contribution of BRCA1 and BRCA2
por: Frank, Thomas S., et al.
Publicado: (1999)

Hereditary Ovarian Carcinoma: Cancer Pathogenesis Looking beyond BRCA1 and BRCA2
por: Samuel, David, et al.
Publicado: (2022)

Mutation Analysis of BRCA1 and BRCA2 in Italian Hereditary and Sporadic Forms of Breast and Ovarian Cancers: Tumor Genotype-Phenotype Correlation in Breast Cancer BRCA-Mutation Carriers
por: Cipollini, G., et al.
Publicado: (1999)

Incidence and impact of brain metastasis in patients with hereditary BRCA1 or BRCA2 mutated invasive breast cancer
por: Garber, Haven R., et al.
Publicado: (2022)

Analysis of PALB2 Gene in BRCA1/BRCA2 Negative Spanish Hereditary Breast/Ovarian Cancer Families with Pancreatic Cancer Cases
por: Blanco, Ana, et al.
Publicado: (2013)

A common SNP in the UNG gene decreases ovarian cancer risk in BRCA2 mutation carriers
por: Baquero, Juan Miguel, et al.
Publicado: (2019)

BRCA1 and BRCA2 in breast cancer families from Wales: moderate mutation frequency and two recurrent mutations in BRCA1.
por: Lancaster, J. M., et al.
Publicado: (1998)

BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2
por: Cline, Melissa S., et al.
Publicado: (2018)

BRCA1 and BRCA2 rearrangements in Brazilian individuals with Hereditary Breast and Ovarian Cancer Syndrome
por: Ewald, Ingrid Petroni, et al.
Publicado: (2016)

Mutational analysis of BRCA1 and BRCA2 genes in Spanish women with early-onset breast cancer
por: Martínez-Ferrandis, JI, et al.
Publicado: (2000)

Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)
por: Osorio, A, et al.
Publicado: (2009)

BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers
por: Maxwell, Kara N., et al.
Publicado: (2017)

Hereditary Ovarian Cancer: Not Only BRCA 1 and 2 Genes
por: Toss, Angela, et al.
Publicado: (2015)

Whole‐exome sequencing of non‐BRCA1/BRCA2 mutation carrier cases at high‐risk for hereditary breast/ovarian cancer
por: Felicio, Paula S., et al.
Publicado: (2020)

Melanoma predisposition—A limited role for germline BRCA1 and BRCA2 variants
por: Adams, David J., et al.
Publicado: (2019)

A model of the BRCA1/BRCA2 network
por: Pujana, MA, et al.
Publicado: (2005)

Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations
por: Gonzalez, R, et al.
Publicado: (1999)

Design and validation of a next generation sequencing assay for hereditary BRCA1 and BRCA2 mutation testing
por: Kang, Hyunseok P., et al.
Publicado: (2016)

The Impact of BRCA1- and BRCA2 Mutations on Ovarian Reserve Status
por: C.E, Drechsel Katja, et al.
Publicado: (2022)

Endometrial Cancer Risk in Women With Germline BRCA1 or BRCA2 Mutations: Multicenter Cohort Study
por: de Jonge, Marthe M, et al.
Publicado: (2021)

Novel BRCA1 and BRCA2 pathogenic mutations in Slovene hereditary breast and ovarian cancer families
por: NOVAKOVIĆ, SRDJAN, et al.
Publicado: (2012)

Genetic and clinical characterization of BRCA-associated hereditary breast and ovarian cancer in Navarra (Spain)
por: Ruiz de Sabando, Ainara, et al.
Publicado: (2019)

The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers
por: Iqbal, J, et al.
Publicado: (2012)

Evaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the consortium of investigators of modifiers of BRCA1/BRCA2
por: Osorio, A, et al.
Publicado: (2011)

Characteristics of small breast and/or ovarian cancer families with germline mutations in BRCA1 and BRCA2
por: Ligtenberg, M J L, et al.
Publicado: (1999)

Hereditary breast cancer – a spectrum of pathogenic mutations and unknown variants of BRCA1 and BRCA2 genes in the Czech Republic: efficiency of testing and clinical follow-up
por: Foretova, L, et al.
Publicado: (2005)

Clinical outcome of prophylactic oophorectomy in BRCA1/BRCA2 mutation carriers and events during follow-up
por: Olivier, R I, et al.
Publicado: (2004)

Case report: Analysis of BRCA1 and BRCA2 gene mutations in a hereditary ovarian cancer family
por: Liao, Ying, et al.
Publicado: (2020)

Prediction of the functional impact of missense variants in BRCA1 and BRCA2 with BRCA-ML
por: Hart, Steven N., et al.
Publicado: (2020)

The rate of the founder Jewish mutations in BRCA1 and BRCA2 in prostate cancer patients in Israel
por: Vazina, A, et al.
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_9uc07hb1mgu9pijdkk7v2l82nr