New insights into the catalytic mechanism of vitamin K epoxide reductase (VKORC1) – The catalytic properties of the major mutations of rVKORC1 explain the biological cost associated to mutations()

The systematic use of antivitamin K anticoagulants (AVK) as rodenticides caused the selection of rats resistant to AVKs. The resistance is mainly associated to genetic polymorphisms in the Vkorc1 gene encoding the VKORC1 enzyme responsible for the reduction of vitamin K 2,3-epoxide to vitamin K. Fiv...

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Detalles Bibliográficos
Autores principales: Matagrin, Benjamin, Hodroge, Ahmed, Montagut-Romans, Adrien, Andru, Julie, Fourel, Isabelle, Besse, Stéphane, Benoit, Etienne, Lattard, Virginie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668507/
https://www.ncbi.nlm.nih.gov/pubmed/23772386
http://dx.doi.org/10.1016/j.fob.2013.02.001

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