Menin mediates epigenetic regulation via histone H3 lysine 9 methylation

Menin, encoded by the multiple endocrine neoplasia type 1 (MEN1) gene, is a tumor suppressor that leads to multiple endocrine tumors upon loss of its function. Menin functions as a transcriptional activator by tethering MLL complex to mediate histone H3 K4 methylation. It also functions as a repress...

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Detalles Bibliográficos
Autores principales: Yang, Y-J, Song, T-Y, Park, J, Lee, J, Lim, J, Jang, H, Kim, Y-N, Yang, J-H, Song, Y, Choi, A, Lee, H Y, Jo, C H, Han, J W, Kim, S-T, Youn, H-D, Cho, E-J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668625/
https://www.ncbi.nlm.nih.gov/pubmed/23579270
http://dx.doi.org/10.1038/cddis.2013.98

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