Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPARβ/δ: a potential therapeutic role for CNS autoimmune disease

12/15-Lipoxygenase (12/15-LO) is an enzyme that converts polyunsaturated fatty acids into bioactive lipid derivatives. In this study, we showed that inhibition of 12/15-LO by baicalein (BA) significantly attenuated clinical severity of experimental autoimmune encephalomyelitis (EAE), an animal model...

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Detalles Bibliográficos
Autores principales: Xu, J, Zhang, Y, Xiao, Y, Ma, S, Liu, Q, Dang, S, Jin, M, Shi, Y, Wan, B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668632/
https://www.ncbi.nlm.nih.gov/pubmed/23559003
http://dx.doi.org/10.1038/cddis.2013.86

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