Mutant Copper-Zinc Superoxide Dismutase (SOD1) Induces Protein Secretion Pathway Alterations and Exosome Release in Astrocytes: IMPLICATIONS FOR DISEASE SPREADING AND MOTOR NEURON PATHOLOGY IN AMYOTROPHIC LATERAL SCLEROSIS

Amyotrophic lateral sclerosis is the most common motor neuron disease and is still incurable. The mechanisms leading to the selective motor neuron vulnerability are still not known. The interplay between motor neurons and astrocytes is crucial in the outcome of the disease. We show that mutant coppe...

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Detalles Bibliográficos
Autores principales: Basso, Manuela, Pozzi, Silvia, Tortarolo, Massimo, Fiordaliso, Fabio, Bisighini, Cinzia, Pasetto, Laura, Spaltro, Gabriella, Lidonnici, Dario, Gensano, Francesco, Battaglia, Elisa, Bendotti, Caterina, Bonetto, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Neurobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668729/
https://www.ncbi.nlm.nih.gov/pubmed/23592792
http://dx.doi.org/10.1074/jbc.M112.425066

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