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Now on display: a gallery of group II intron structures at different stages of catalysis
Group II introns are mobile genetic elements that self-splice and retrotranspose into DNA and RNA. They are considered evolutionary ancestors of the spliceosome, the ribonucleoprotein complex essential for pre-mRNA processing in higher eukaryotes. Over a 20-year period, group II introns have been ch...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669008/ https://www.ncbi.nlm.nih.gov/pubmed/23634971 http://dx.doi.org/10.1186/1759-8753-4-14 |
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author | Marcia, Marco Somarowthu, Srinivas Pyle, Anna Marie |
author_facet | Marcia, Marco Somarowthu, Srinivas Pyle, Anna Marie |
author_sort | Marcia, Marco |
collection | PubMed |
description | Group II introns are mobile genetic elements that self-splice and retrotranspose into DNA and RNA. They are considered evolutionary ancestors of the spliceosome, the ribonucleoprotein complex essential for pre-mRNA processing in higher eukaryotes. Over a 20-year period, group II introns have been characterized first genetically, then biochemically, and finally by means of X-ray crystallography. To date, 17 crystal structures of a group II intron are available, representing five different stages of the splicing cycle. This review provides a framework for classifying and understanding these new structures in the context of the splicing cycle. Structural and functional implications for the spliceosome are also discussed. |
format | Online Article Text |
id | pubmed-3669008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36690082013-06-01 Now on display: a gallery of group II intron structures at different stages of catalysis Marcia, Marco Somarowthu, Srinivas Pyle, Anna Marie Mob DNA Review Group II introns are mobile genetic elements that self-splice and retrotranspose into DNA and RNA. They are considered evolutionary ancestors of the spliceosome, the ribonucleoprotein complex essential for pre-mRNA processing in higher eukaryotes. Over a 20-year period, group II introns have been characterized first genetically, then biochemically, and finally by means of X-ray crystallography. To date, 17 crystal structures of a group II intron are available, representing five different stages of the splicing cycle. This review provides a framework for classifying and understanding these new structures in the context of the splicing cycle. Structural and functional implications for the spliceosome are also discussed. BioMed Central 2013-05-01 /pmc/articles/PMC3669008/ /pubmed/23634971 http://dx.doi.org/10.1186/1759-8753-4-14 Text en Copyright © 2013 Marcia et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Marcia, Marco Somarowthu, Srinivas Pyle, Anna Marie Now on display: a gallery of group II intron structures at different stages of catalysis |
title | Now on display: a gallery of group II intron structures at different stages of catalysis |
title_full | Now on display: a gallery of group II intron structures at different stages of catalysis |
title_fullStr | Now on display: a gallery of group II intron structures at different stages of catalysis |
title_full_unstemmed | Now on display: a gallery of group II intron structures at different stages of catalysis |
title_short | Now on display: a gallery of group II intron structures at different stages of catalysis |
title_sort | now on display: a gallery of group ii intron structures at different stages of catalysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669008/ https://www.ncbi.nlm.nih.gov/pubmed/23634971 http://dx.doi.org/10.1186/1759-8753-4-14 |
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