Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene delivery

Cationic liposome (lipoplex) and polymer (polyplex)-based vectors have been developed for nonviral gene delivery. These vectors bind DNA and enter cells via endosomes, but intracellular transfer of DNA to the nucleus is inefficient. Here we show that lipoplex and polyplex vectors enter cells in endo...

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Detalles Bibliográficos
Autores principales: Roberts, Rebecca, Al-Jamal, Wafa’ T., Whelband, Matthew, Thomas, Paul, Jefferson, Matthew, van den Bossche, Jeroen, Powell, Penny P., Kostarelos, Kostas, Wileman, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Basic Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669178/
https://www.ncbi.nlm.nih.gov/pubmed/23422759
http://dx.doi.org/10.4161/auto.23877

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