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Association of Cardiovascular Burden with Mobility Limitation among Elderly People: A Population-Based Study

BACKGROUND: Cardiovascular risk factors (CRFs) such as smoking and diabetes have been associated with mobility limitations among older adults. We seek to examine to what extent individual and aggregated CRFs and cardiovascular diseases (CVDs) are associated with mobility limitation. METHODS: The stu...

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Autores principales: Welmer, Anna-Karin, Angleman, Sara, Rydwik, Elisabeth, Fratiglioni, Laura, Qiu, Chengxuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669202/
https://www.ncbi.nlm.nih.gov/pubmed/23741513
http://dx.doi.org/10.1371/journal.pone.0065815
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author Welmer, Anna-Karin
Angleman, Sara
Rydwik, Elisabeth
Fratiglioni, Laura
Qiu, Chengxuan
author_facet Welmer, Anna-Karin
Angleman, Sara
Rydwik, Elisabeth
Fratiglioni, Laura
Qiu, Chengxuan
author_sort Welmer, Anna-Karin
collection PubMed
description BACKGROUND: Cardiovascular risk factors (CRFs) such as smoking and diabetes have been associated with mobility limitations among older adults. We seek to examine to what extent individual and aggregated CRFs and cardiovascular diseases (CVDs) are associated with mobility limitation. METHODS: The study sample included 2725 participants (age ≥60 years, mean age 72.7 years, 62% women) in the Swedish National Study on Aging and Care in the Kungsholmen district of central Stockholm, Sweden, who were living either at their own home or in institutions. Data on demographic features, CRFs, and CVDs were collected through interview, clinical examination, self-reported history, laboratory tests, and inpatient register. Mobility limitation was defined as walking speed <0.8 m/s. Data were analyzed using multiple logistic models controlling for potential confounders. RESULTS: Of the 2725 participants, 581 (21.3%) had mobility limitation. The likelihood of mobility limitation increased linearly with the increasing number of CRFs (i.e., hypertension, high C-reactive protein, obesity, diabetes and smoking) (p for linear trend<0.010) and of CVDs (i.e., ischemic heart disease, atrial fibrillation, heart failure and stroke) (p for linear trend<0.001). There were statistical interactions of aggregated CRFs with age and APOE ε4 allele on mobility limitation (p (interaction)<0.05), such that the association of mobility limitation with aggregated CRFs was statistically evident only among people aged <80 years and among carriers of the APOE ε4 allele. CONCLUSION: Aggregations of multiple CRFs and CVDs are associated with an increased likelihood of mobility limitation among older adults; however the associations of CRFs with mobility limitation vary by age and genetic susceptibility.
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spelling pubmed-36692022013-06-05 Association of Cardiovascular Burden with Mobility Limitation among Elderly People: A Population-Based Study Welmer, Anna-Karin Angleman, Sara Rydwik, Elisabeth Fratiglioni, Laura Qiu, Chengxuan PLoS One Research Article BACKGROUND: Cardiovascular risk factors (CRFs) such as smoking and diabetes have been associated with mobility limitations among older adults. We seek to examine to what extent individual and aggregated CRFs and cardiovascular diseases (CVDs) are associated with mobility limitation. METHODS: The study sample included 2725 participants (age ≥60 years, mean age 72.7 years, 62% women) in the Swedish National Study on Aging and Care in the Kungsholmen district of central Stockholm, Sweden, who were living either at their own home or in institutions. Data on demographic features, CRFs, and CVDs were collected through interview, clinical examination, self-reported history, laboratory tests, and inpatient register. Mobility limitation was defined as walking speed <0.8 m/s. Data were analyzed using multiple logistic models controlling for potential confounders. RESULTS: Of the 2725 participants, 581 (21.3%) had mobility limitation. The likelihood of mobility limitation increased linearly with the increasing number of CRFs (i.e., hypertension, high C-reactive protein, obesity, diabetes and smoking) (p for linear trend<0.010) and of CVDs (i.e., ischemic heart disease, atrial fibrillation, heart failure and stroke) (p for linear trend<0.001). There were statistical interactions of aggregated CRFs with age and APOE ε4 allele on mobility limitation (p (interaction)<0.05), such that the association of mobility limitation with aggregated CRFs was statistically evident only among people aged <80 years and among carriers of the APOE ε4 allele. CONCLUSION: Aggregations of multiple CRFs and CVDs are associated with an increased likelihood of mobility limitation among older adults; however the associations of CRFs with mobility limitation vary by age and genetic susceptibility. Public Library of Science 2013-05-31 /pmc/articles/PMC3669202/ /pubmed/23741513 http://dx.doi.org/10.1371/journal.pone.0065815 Text en © 2013 Welmer et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Welmer, Anna-Karin
Angleman, Sara
Rydwik, Elisabeth
Fratiglioni, Laura
Qiu, Chengxuan
Association of Cardiovascular Burden with Mobility Limitation among Elderly People: A Population-Based Study
title Association of Cardiovascular Burden with Mobility Limitation among Elderly People: A Population-Based Study
title_full Association of Cardiovascular Burden with Mobility Limitation among Elderly People: A Population-Based Study
title_fullStr Association of Cardiovascular Burden with Mobility Limitation among Elderly People: A Population-Based Study
title_full_unstemmed Association of Cardiovascular Burden with Mobility Limitation among Elderly People: A Population-Based Study
title_short Association of Cardiovascular Burden with Mobility Limitation among Elderly People: A Population-Based Study
title_sort association of cardiovascular burden with mobility limitation among elderly people: a population-based study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669202/
https://www.ncbi.nlm.nih.gov/pubmed/23741513
http://dx.doi.org/10.1371/journal.pone.0065815
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