DGCR8-Mediated Production of Canonical Micrornas Is Critical for Regulatory T Cell Function and Stability

Regulatory T cells (Treg) are integral for immune homeostasis. Here we demonstrate that canonical microRNAs (miRNAs) are required for Treg function because mice with DGCR8-deficient Treg cells spontaneously develop a scurfy-like disease. Using genetic lineage marking we show that absence of miRNAs l...

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Detalles Bibliográficos
Autores principales: Jeker, Lukas T., Zhou, Xuyu, Blelloch, Robert, Bluestone, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669207/
https://www.ncbi.nlm.nih.gov/pubmed/23741528
http://dx.doi.org/10.1371/journal.pone.0066282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669207/
https://www.ncbi.nlm.nih.gov/pubmed/23741528
http://dx.doi.org/10.1371/journal.pone.0066282

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