Cargando…
DGCR8-Mediated Production of Canonical Micrornas Is Critical for Regulatory T Cell Function and Stability
Regulatory T cells (Treg) are integral for immune homeostasis. Here we demonstrate that canonical microRNAs (miRNAs) are required for Treg function because mice with DGCR8-deficient Treg cells spontaneously develop a scurfy-like disease. Using genetic lineage marking we show that absence of miRNAs l...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669207/ https://www.ncbi.nlm.nih.gov/pubmed/23741528 http://dx.doi.org/10.1371/journal.pone.0066282 |