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Claims-Based Definition of Death in Japanese Claims Database: Validity and Implications
BACKGROUND: For the pending National Claims Database in Japan, researchers will not have access to death information in the enrollment files. We developed and evaluated a claims-based definition of death. METHODOLOGY/PRINCIPAL FINDINGS: We used healthcare claims and enrollment data between January 2...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669209/ https://www.ncbi.nlm.nih.gov/pubmed/23741526 http://dx.doi.org/10.1371/journal.pone.0066116 |
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author | Ooba, Nobuhiro Setoguchi, Soko Ando, Takashi Sato, Tsugumichi Yamaguchi, Takuhiro Mochizuki, Mayumi Kubota, Kiyoshi |
author_facet | Ooba, Nobuhiro Setoguchi, Soko Ando, Takashi Sato, Tsugumichi Yamaguchi, Takuhiro Mochizuki, Mayumi Kubota, Kiyoshi |
author_sort | Ooba, Nobuhiro |
collection | PubMed |
description | BACKGROUND: For the pending National Claims Database in Japan, researchers will not have access to death information in the enrollment files. We developed and evaluated a claims-based definition of death. METHODOLOGY/PRINCIPAL FINDINGS: We used healthcare claims and enrollment data between January 2005 and August 2009 for 195,193 beneficiaries aged 20 to 74 in 3 private health insurance unions. We developed claims-based definitions of death using discharge or disease status and Charlson comorbidity index (CCI). We calculated sensitivity, specificity and positive predictive values (PPVs) using the enrollment data as a gold standard in the overall population and subgroups divided by demographic and other factors. We also assessed bias and precision in two example studies where an outcome was death. The definition based on the combination of discharge/disease status and CCI provided moderate sensitivity (around 60%) and high specificity (99.99%) and high PPVs (94.8%). In most subgroups, sensitivity of the preferred definition was also around 60% but varied from 28 to 91%. In an example study comparing death rates between two anticancer drug classes, the claims-based definition provided valid and precise hazard ratios (HRs). In another example study comparing two classes of anti-depressants, the HR with the claims-based definition was biased and had lower precision than that with the gold standard definition. CONCLUSIONS/SIGNIFICANCE: The claims-based definitions of death developed in this study had high specificity and PPVs while sensitivity was around 60%. The definitions will be useful in future studies when used with attention to the possible fluctuation of sensitivity in some subpopulations. |
format | Online Article Text |
id | pubmed-3669209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36692092013-06-05 Claims-Based Definition of Death in Japanese Claims Database: Validity and Implications Ooba, Nobuhiro Setoguchi, Soko Ando, Takashi Sato, Tsugumichi Yamaguchi, Takuhiro Mochizuki, Mayumi Kubota, Kiyoshi PLoS One Research Article BACKGROUND: For the pending National Claims Database in Japan, researchers will not have access to death information in the enrollment files. We developed and evaluated a claims-based definition of death. METHODOLOGY/PRINCIPAL FINDINGS: We used healthcare claims and enrollment data between January 2005 and August 2009 for 195,193 beneficiaries aged 20 to 74 in 3 private health insurance unions. We developed claims-based definitions of death using discharge or disease status and Charlson comorbidity index (CCI). We calculated sensitivity, specificity and positive predictive values (PPVs) using the enrollment data as a gold standard in the overall population and subgroups divided by demographic and other factors. We also assessed bias and precision in two example studies where an outcome was death. The definition based on the combination of discharge/disease status and CCI provided moderate sensitivity (around 60%) and high specificity (99.99%) and high PPVs (94.8%). In most subgroups, sensitivity of the preferred definition was also around 60% but varied from 28 to 91%. In an example study comparing death rates between two anticancer drug classes, the claims-based definition provided valid and precise hazard ratios (HRs). In another example study comparing two classes of anti-depressants, the HR with the claims-based definition was biased and had lower precision than that with the gold standard definition. CONCLUSIONS/SIGNIFICANCE: The claims-based definitions of death developed in this study had high specificity and PPVs while sensitivity was around 60%. The definitions will be useful in future studies when used with attention to the possible fluctuation of sensitivity in some subpopulations. Public Library of Science 2013-05-31 /pmc/articles/PMC3669209/ /pubmed/23741526 http://dx.doi.org/10.1371/journal.pone.0066116 Text en © 2013 Ooba et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Ooba, Nobuhiro Setoguchi, Soko Ando, Takashi Sato, Tsugumichi Yamaguchi, Takuhiro Mochizuki, Mayumi Kubota, Kiyoshi Claims-Based Definition of Death in Japanese Claims Database: Validity and Implications |
title | Claims-Based Definition of Death in Japanese Claims Database: Validity and Implications |
title_full | Claims-Based Definition of Death in Japanese Claims Database: Validity and Implications |
title_fullStr | Claims-Based Definition of Death in Japanese Claims Database: Validity and Implications |
title_full_unstemmed | Claims-Based Definition of Death in Japanese Claims Database: Validity and Implications |
title_short | Claims-Based Definition of Death in Japanese Claims Database: Validity and Implications |
title_sort | claims-based definition of death in japanese claims database: validity and implications |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669209/ https://www.ncbi.nlm.nih.gov/pubmed/23741526 http://dx.doi.org/10.1371/journal.pone.0066116 |
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