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In Vivo Visualization of Notch1 Proteolysis Reveals the Heterogeneity of Notch1 Signaling Activity in the Mouse Cochlea

Mechanosensory hair cells (HCs) and surrounding supporting cells (SCs) in the mouse cochlea are important for hearing and are derived from the same prosensory progenitors. Notch1 signaling plays dual but contrasting and age-dependent roles in mouse cochlear development: early lateral induction and s...

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Detalles Bibliográficos
Autores principales: Liu, Zhiyong, Liu, Zhenyi, Walters, Bradley J., Owen, Thomas, Kopan, Raphael, Zuo, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669271/
https://www.ncbi.nlm.nih.gov/pubmed/23741415
http://dx.doi.org/10.1371/journal.pone.0064903