Comparison of Modules of Wild Type and Mutant Huntingtin and TP53 Protein Interaction Networks: Implications in Biological Processes and Functions

Disease-causing mutations usually change the interacting partners of mutant proteins. In this article, we propose that the biological consequences of mutation are directly related to the alteration of corresponding protein protein interaction networks (PPIN). Mutation of Huntingtin (HTT) which cause...

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Detalles Bibliográficos
Autores principales: Basu, Mahashweta, Bhattacharyya, Nitai P., Mohanty, Pradeep K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669416/
https://www.ncbi.nlm.nih.gov/pubmed/23741403
http://dx.doi.org/10.1371/journal.pone.0064838

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