Coarse-Grained/Molecular Mechanics of the TAS2R38 Bitter Taste Receptor: Experimentally-Validated Detailed Structural Prediction of Agonist Binding

Bitter molecules in humans are detected by ∼25 G protein-coupled receptors (GPCRs). The lack of atomic resolution structure for any of them is complicating an in depth understanding of the molecular mechanisms underlying bitter taste perception. Here, we investigate the molecular determinants of the...

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Detalles Bibliográficos
Autores principales: Marchiori, Alessandro, Capece, Luciana, Giorgetti, Alejandro, Gasparini, Paolo, Behrens, Maik, Carloni, Paolo, Meyerhof, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669430/
https://www.ncbi.nlm.nih.gov/pubmed/23741366
http://dx.doi.org/10.1371/journal.pone.0064675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669430/
https://www.ncbi.nlm.nih.gov/pubmed/23741366
http://dx.doi.org/10.1371/journal.pone.0064675

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