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Biosynthesis and biological function of sulfoglycolipids
Sulfation confers negative charge on glycolipids and the attached sulfate group presents a part of determinants for the molecular interactions. Mammalian sulfoglycolipids are comprised of two major members, sulfatide (SO(3)-3Gal-ceramide) and seminolipid (SO(3)-3Gal-alkylacylglycerol). Sulfatide is...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japan Academy
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669731/ https://www.ncbi.nlm.nih.gov/pubmed/23574804 http://dx.doi.org/10.2183/pjab.89.129 |
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author | HONKE, Koichi |
author_facet | HONKE, Koichi |
author_sort | HONKE, Koichi |
collection | PubMed |
description | Sulfation confers negative charge on glycolipids and the attached sulfate group presents a part of determinants for the molecular interactions. Mammalian sulfoglycolipids are comprised of two major members, sulfatide (SO(3)-3Gal-ceramide) and seminolipid (SO(3)-3Gal-alkylacylglycerol). Sulfatide is abundant in the myelin sheath and seminolipid is unique to the spermatogenic cells. The carbohydrate moiety of sulfatide and seminolipid is biosynthesized via sequential reactions catalyzed by common enzymes: ceramide galactosyltransferase (CGT) and cerebroside sulfotransferase (CST). To elucidate the biological function of sulfoglycolipids, we have purified CST, cloned the CST gene, and generated CST-knockout mice. CST-null mice completely lack sulfoglycolipids all over the body. CST-null mice manifest some neurological disorders due to myelin dysfunction, an aberrant enhancement of oligodendrocyte terminal differentiation, and an arrest of spermatogenesis. CST-deficiency ameliorates L-selectin-dependent monocyte infiltration in the renal interstitial inflammation, indicating that sulfatide is an endogenous ligand of L-selectin. Studies on the molecular mechanisms underlying the biological events for which sulfoglycolipids are essential are ongoing. |
format | Online Article Text |
id | pubmed-3669731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Japan Academy |
record_format | MEDLINE/PubMed |
spelling | pubmed-36697312013-07-17 Biosynthesis and biological function of sulfoglycolipids HONKE, Koichi Proc Jpn Acad Ser B Phys Biol Sci Review Sulfation confers negative charge on glycolipids and the attached sulfate group presents a part of determinants for the molecular interactions. Mammalian sulfoglycolipids are comprised of two major members, sulfatide (SO(3)-3Gal-ceramide) and seminolipid (SO(3)-3Gal-alkylacylglycerol). Sulfatide is abundant in the myelin sheath and seminolipid is unique to the spermatogenic cells. The carbohydrate moiety of sulfatide and seminolipid is biosynthesized via sequential reactions catalyzed by common enzymes: ceramide galactosyltransferase (CGT) and cerebroside sulfotransferase (CST). To elucidate the biological function of sulfoglycolipids, we have purified CST, cloned the CST gene, and generated CST-knockout mice. CST-null mice completely lack sulfoglycolipids all over the body. CST-null mice manifest some neurological disorders due to myelin dysfunction, an aberrant enhancement of oligodendrocyte terminal differentiation, and an arrest of spermatogenesis. CST-deficiency ameliorates L-selectin-dependent monocyte infiltration in the renal interstitial inflammation, indicating that sulfatide is an endogenous ligand of L-selectin. Studies on the molecular mechanisms underlying the biological events for which sulfoglycolipids are essential are ongoing. The Japan Academy 2013-04-11 /pmc/articles/PMC3669731/ /pubmed/23574804 http://dx.doi.org/10.2183/pjab.89.129 Text en © 2013 The Japan Academy This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review HONKE, Koichi Biosynthesis and biological function of sulfoglycolipids |
title | Biosynthesis and biological function of sulfoglycolipids |
title_full | Biosynthesis and biological function of sulfoglycolipids |
title_fullStr | Biosynthesis and biological function of sulfoglycolipids |
title_full_unstemmed | Biosynthesis and biological function of sulfoglycolipids |
title_short | Biosynthesis and biological function of sulfoglycolipids |
title_sort | biosynthesis and biological function of sulfoglycolipids |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669731/ https://www.ncbi.nlm.nih.gov/pubmed/23574804 http://dx.doi.org/10.2183/pjab.89.129 |
work_keys_str_mv | AT honkekoichi biosynthesisandbiologicalfunctionofsulfoglycolipids |