Docking studies of piperine - iron conjugate with human CYP450 3A4

Piperine, a major constituent of Piper nigrum (Black pepper), is one of the well known components in many Ayurvedic formulations. Piperine is most studied bioenhancer because it inhibits drug metabolizing enzymes in rodents and increases plasma concentrations of several drugs, including P-glycoprote...

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Autores principales: Alugolu, Veerabrahmam, Rentala, Satyanarayana, Komarraju, Aruna Lakshmi, Parimi, Uma Devi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2013
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669784/
https://www.ncbi.nlm.nih.gov/pubmed/23750076
http://dx.doi.org/10.6026/97320630009334
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author Alugolu, Veerabrahmam
Rentala, Satyanarayana
Komarraju, Aruna Lakshmi
Parimi, Uma Devi
author_facet Alugolu, Veerabrahmam
Rentala, Satyanarayana
Komarraju, Aruna Lakshmi
Parimi, Uma Devi
author_sort Alugolu, Veerabrahmam
collection PubMed
description Piperine, a major constituent of Piper nigrum (Black pepper), is one of the well known components in many Ayurvedic formulations. Piperine is most studied bioenhancer because it inhibits drug metabolizing enzymes in rodents and increases plasma concentrations of several drugs, including P-glycoprotein substrates. However, there areno evidences on piperine-iron conjugate to inhibit human CYP450 3A4. We therefore investigated the influence of piperine-Fe conjugate to study the metabolism of iron with CYP450 3A4. Our in silico results showed that Piperine when conjugated with iron, inhibited activity of CYP450 3A4. This improved the binding of piperine-Fe conjugate with CYP450 3A4 and increased bioavailability.
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spelling pubmed-36697842013-06-07 Docking studies of piperine - iron conjugate with human CYP450 3A4 Alugolu, Veerabrahmam Rentala, Satyanarayana Komarraju, Aruna Lakshmi Parimi, Uma Devi Bioinformation Hypothesis Piperine, a major constituent of Piper nigrum (Black pepper), is one of the well known components in many Ayurvedic formulations. Piperine is most studied bioenhancer because it inhibits drug metabolizing enzymes in rodents and increases plasma concentrations of several drugs, including P-glycoprotein substrates. However, there areno evidences on piperine-iron conjugate to inhibit human CYP450 3A4. We therefore investigated the influence of piperine-Fe conjugate to study the metabolism of iron with CYP450 3A4. Our in silico results showed that Piperine when conjugated with iron, inhibited activity of CYP450 3A4. This improved the binding of piperine-Fe conjugate with CYP450 3A4 and increased bioavailability. Biomedical Informatics 2013-04-13 /pmc/articles/PMC3669784/ /pubmed/23750076 http://dx.doi.org/10.6026/97320630009334 Text en © 2013 Biomedical Informatics This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Alugolu, Veerabrahmam
Rentala, Satyanarayana
Komarraju, Aruna Lakshmi
Parimi, Uma Devi
Docking studies of piperine - iron conjugate with human CYP450 3A4
title Docking studies of piperine - iron conjugate with human CYP450 3A4
title_full Docking studies of piperine - iron conjugate with human CYP450 3A4
title_fullStr Docking studies of piperine - iron conjugate with human CYP450 3A4
title_full_unstemmed Docking studies of piperine - iron conjugate with human CYP450 3A4
title_short Docking studies of piperine - iron conjugate with human CYP450 3A4
title_sort docking studies of piperine - iron conjugate with human cyp450 3a4
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669784/
https://www.ncbi.nlm.nih.gov/pubmed/23750076
http://dx.doi.org/10.6026/97320630009334
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