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On the morphogenesis of glial compartments in the sensory organs of Caenorhabditis elegans

Glial cells surround neuronal endings and isolate them within specialized compartments. This architecture is found at synapses in the central nervous system, as well as at receptive endings of sensory neurons. Recent studies are beginning to uncover the contributions of glial compartments to the fun...

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Detalles Bibliográficos
Autores principales: Oikonomou, Grigorios, Shaham, Shai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670172/
https://www.ncbi.nlm.nih.gov/pubmed/24058823
http://dx.doi.org/10.4161/worm.19343
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author Oikonomou, Grigorios
Shaham, Shai
author_facet Oikonomou, Grigorios
Shaham, Shai
author_sort Oikonomou, Grigorios
collection PubMed
description Glial cells surround neuronal endings and isolate them within specialized compartments. This architecture is found at synapses in the central nervous system, as well as at receptive endings of sensory neurons. Recent studies are beginning to uncover the contributions of glial compartments to the functions of the ensheathed neurons. However, the cellular and molecular processes that guide compartment morphogenesis remain unknown. The main sensory organ of Caenorhabditis elegans, the amphid, provides an experimentally tractable setting in which to address the mechanisms underlying glial compartment formation. Amphid development is stereotyped and amphid structure is easily assayed. We recently uncovered a molecular tug of war that regulates the size of the amphid sensory compartment. The Nemo-like kinase LIT-1 interacts with the glial cytoskeleton to promote compartment growth, a process that also involves components of the retromer complex, while the Patched-related transmembrane protein DAF-6 keeps this expansion in check. Here we discuss how regulation of secretion by the cytoskeleton could guide the sculpting of glial compartments.
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spelling pubmed-36701722013-09-19 On the morphogenesis of glial compartments in the sensory organs of Caenorhabditis elegans Oikonomou, Grigorios Shaham, Shai Worm Commentary Glial cells surround neuronal endings and isolate them within specialized compartments. This architecture is found at synapses in the central nervous system, as well as at receptive endings of sensory neurons. Recent studies are beginning to uncover the contributions of glial compartments to the functions of the ensheathed neurons. However, the cellular and molecular processes that guide compartment morphogenesis remain unknown. The main sensory organ of Caenorhabditis elegans, the amphid, provides an experimentally tractable setting in which to address the mechanisms underlying glial compartment formation. Amphid development is stereotyped and amphid structure is easily assayed. We recently uncovered a molecular tug of war that regulates the size of the amphid sensory compartment. The Nemo-like kinase LIT-1 interacts with the glial cytoskeleton to promote compartment growth, a process that also involves components of the retromer complex, while the Patched-related transmembrane protein DAF-6 keeps this expansion in check. Here we discuss how regulation of secretion by the cytoskeleton could guide the sculpting of glial compartments. Landes Bioscience 2012-01-01 /pmc/articles/PMC3670172/ /pubmed/24058823 http://dx.doi.org/10.4161/worm.19343 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Commentary
Oikonomou, Grigorios
Shaham, Shai
On the morphogenesis of glial compartments in the sensory organs of Caenorhabditis elegans
title On the morphogenesis of glial compartments in the sensory organs of Caenorhabditis elegans
title_full On the morphogenesis of glial compartments in the sensory organs of Caenorhabditis elegans
title_fullStr On the morphogenesis of glial compartments in the sensory organs of Caenorhabditis elegans
title_full_unstemmed On the morphogenesis of glial compartments in the sensory organs of Caenorhabditis elegans
title_short On the morphogenesis of glial compartments in the sensory organs of Caenorhabditis elegans
title_sort on the morphogenesis of glial compartments in the sensory organs of caenorhabditis elegans
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670172/
https://www.ncbi.nlm.nih.gov/pubmed/24058823
http://dx.doi.org/10.4161/worm.19343
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