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The G protein regulator AGS-3 allows C. elegans to alter behaviors in response to food deprivation
Behavioral responses to food deprivation are a fundamental aspect of nervous system function in all animals. In humans, these behavioral responses prevent dieting from being an effective remedy for obesity. Several signaling molecules in the mammalian brain act through G proteins of the Gα(i/o) fami...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670173/ https://www.ncbi.nlm.nih.gov/pubmed/24058824 http://dx.doi.org/10.4161/worm.19042 |
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author | Hofler, Catherine Koelle, Michael R. |
author_facet | Hofler, Catherine Koelle, Michael R. |
author_sort | Hofler, Catherine |
collection | PubMed |
description | Behavioral responses to food deprivation are a fundamental aspect of nervous system function in all animals. In humans, these behavioral responses prevent dieting from being an effective remedy for obesity. Several signaling molecules in the mammalian brain act through G proteins of the Gα(i/o) family to mediate responses to food restriction. The mechanisms for neural response to food deprivation may be conserved across species, allowing the power of genetic model organisms to generate insights relevant to the problem of human obesity. In a recent study, we found that C. elegans uses Gα(o) signaling to mediate a number of behavioral changes that occur after food deprivation. Food deprivation causes biochemical changes in the G Protein Regulator (GPR) domain protein AGS-3 and AGS-3, together with the guanine nucleotide exchange factor RIC-8, activates Gα(o) signaling to alter food-seeking behavior. These proteins are all conserved in the human brain. Thus the study of behavioral responses to food deprivation in C. elegans may reveal the details of conserved molecular mechanisms underlying neural responses to food deprivation. |
format | Online Article Text |
id | pubmed-3670173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-36701732013-09-19 The G protein regulator AGS-3 allows C. elegans to alter behaviors in response to food deprivation Hofler, Catherine Koelle, Michael R. Worm Commentary Behavioral responses to food deprivation are a fundamental aspect of nervous system function in all animals. In humans, these behavioral responses prevent dieting from being an effective remedy for obesity. Several signaling molecules in the mammalian brain act through G proteins of the Gα(i/o) family to mediate responses to food restriction. The mechanisms for neural response to food deprivation may be conserved across species, allowing the power of genetic model organisms to generate insights relevant to the problem of human obesity. In a recent study, we found that C. elegans uses Gα(o) signaling to mediate a number of behavioral changes that occur after food deprivation. Food deprivation causes biochemical changes in the G Protein Regulator (GPR) domain protein AGS-3 and AGS-3, together with the guanine nucleotide exchange factor RIC-8, activates Gα(o) signaling to alter food-seeking behavior. These proteins are all conserved in the human brain. Thus the study of behavioral responses to food deprivation in C. elegans may reveal the details of conserved molecular mechanisms underlying neural responses to food deprivation. Landes Bioscience 2012-01-01 /pmc/articles/PMC3670173/ /pubmed/24058824 http://dx.doi.org/10.4161/worm.19042 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Commentary Hofler, Catherine Koelle, Michael R. The G protein regulator AGS-3 allows C. elegans to alter behaviors in response to food deprivation |
title | The G protein regulator AGS-3 allows C. elegans to alter behaviors in response to food deprivation |
title_full | The G protein regulator AGS-3 allows C. elegans to alter behaviors in response to food deprivation |
title_fullStr | The G protein regulator AGS-3 allows C. elegans to alter behaviors in response to food deprivation |
title_full_unstemmed | The G protein regulator AGS-3 allows C. elegans to alter behaviors in response to food deprivation |
title_short | The G protein regulator AGS-3 allows C. elegans to alter behaviors in response to food deprivation |
title_sort | g protein regulator ags-3 allows c. elegans to alter behaviors in response to food deprivation |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670173/ https://www.ncbi.nlm.nih.gov/pubmed/24058824 http://dx.doi.org/10.4161/worm.19042 |
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