Nuclear positioning in the gonadal distal tip cells of C. elegans

Morphogenesis of the hermaphrodite gonad of Caenorhabditis elegans is directed by the U-shaped migration of the gonadal leader cells, which are called distal tip cells (DTCs). The nuclei of migrating DTCs are always positioned at the leading edge of the cells, even as these cells turn dorsally to co...

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Detalles Bibliográficos
Autores principales: Kim, Hon-Song, Nishiwaki, Kiyoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670225/
https://www.ncbi.nlm.nih.gov/pubmed/24058833
http://dx.doi.org/10.4161/worm.19500
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author Kim, Hon-Song
Nishiwaki, Kiyoji
author_facet Kim, Hon-Song
Nishiwaki, Kiyoji
author_sort Kim, Hon-Song
collection PubMed
description Morphogenesis of the hermaphrodite gonad of Caenorhabditis elegans is directed by the U-shaped migration of the gonadal leader cells, which are called distal tip cells (DTCs). The nuclei of migrating DTCs are always positioned at the leading edge of the cells, even as these cells turn dorsally to contact the hypodermis and intestine. When the DTCs turn dorsally, VAB-10B1/spectraplakin acts in nuclear translocation by regulating the polarized growth of microtubules. The function of spectraplakin in nuclear positioning may be evolutionarily conserved. Here we discuss the possible reason for leading-edge positioning of the DTC nucleus.
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spelling pubmed-36702252013-09-19 Nuclear positioning in the gonadal distal tip cells of C. elegans Kim, Hon-Song Nishiwaki, Kiyoji Worm Commentary Morphogenesis of the hermaphrodite gonad of Caenorhabditis elegans is directed by the U-shaped migration of the gonadal leader cells, which are called distal tip cells (DTCs). The nuclei of migrating DTCs are always positioned at the leading edge of the cells, even as these cells turn dorsally to contact the hypodermis and intestine. When the DTCs turn dorsally, VAB-10B1/spectraplakin acts in nuclear translocation by regulating the polarized growth of microtubules. The function of spectraplakin in nuclear positioning may be evolutionarily conserved. Here we discuss the possible reason for leading-edge positioning of the DTC nucleus. Landes Bioscience 2012-04-01 /pmc/articles/PMC3670225/ /pubmed/24058833 http://dx.doi.org/10.4161/worm.19500 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Commentary
Kim, Hon-Song
Nishiwaki, Kiyoji
Nuclear positioning in the gonadal distal tip cells of C. elegans
title Nuclear positioning in the gonadal distal tip cells of C. elegans
title_full Nuclear positioning in the gonadal distal tip cells of C. elegans
title_fullStr Nuclear positioning in the gonadal distal tip cells of C. elegans
title_full_unstemmed Nuclear positioning in the gonadal distal tip cells of C. elegans
title_short Nuclear positioning in the gonadal distal tip cells of C. elegans
title_sort nuclear positioning in the gonadal distal tip cells of c. elegans
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670225/
https://www.ncbi.nlm.nih.gov/pubmed/24058833
http://dx.doi.org/10.4161/worm.19500
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