Evolution of the JAK-STAT pathway

The JAK-STAT pathway represents a finely tuned orchestra capable of rapidly facilitating an exquisite symphony of responses from a complex array of extracellular signals. This review explores the evolution of the JAK-STAT pathway: the origins of the individual domains from which it is constructed, t...

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Detalles Bibliográficos
Autores principales: Liongue, Clifford, Ward, Alister C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670263/
https://www.ncbi.nlm.nih.gov/pubmed/24058787
http://dx.doi.org/10.4161/jkst.22756
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author Liongue, Clifford
Ward, Alister C.
author_facet Liongue, Clifford
Ward, Alister C.
author_sort Liongue, Clifford
collection PubMed
description The JAK-STAT pathway represents a finely tuned orchestra capable of rapidly facilitating an exquisite symphony of responses from a complex array of extracellular signals. This review explores the evolution of the JAK-STAT pathway: the origins of the individual domains from which it is constructed, the formation of individual components from these basic building blocks, the assembly of the components into a functional pathway, and the subsequent reiteration of this basic template to fulfill a variety of roles downstream of cytokine receptors.
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spelling pubmed-36702632013-09-19 Evolution of the JAK-STAT pathway Liongue, Clifford Ward, Alister C. JAKSTAT Review The JAK-STAT pathway represents a finely tuned orchestra capable of rapidly facilitating an exquisite symphony of responses from a complex array of extracellular signals. This review explores the evolution of the JAK-STAT pathway: the origins of the individual domains from which it is constructed, the formation of individual components from these basic building blocks, the assembly of the components into a functional pathway, and the subsequent reiteration of this basic template to fulfill a variety of roles downstream of cytokine receptors. Landes Bioscience 2013-01-01 2013-01-01 /pmc/articles/PMC3670263/ /pubmed/24058787 http://dx.doi.org/10.4161/jkst.22756 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Liongue, Clifford
Ward, Alister C.
Evolution of the JAK-STAT pathway
title Evolution of the JAK-STAT pathway
title_full Evolution of the JAK-STAT pathway
title_fullStr Evolution of the JAK-STAT pathway
title_full_unstemmed Evolution of the JAK-STAT pathway
title_short Evolution of the JAK-STAT pathway
title_sort evolution of the jak-stat pathway
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670263/
https://www.ncbi.nlm.nih.gov/pubmed/24058787
http://dx.doi.org/10.4161/jkst.22756
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