The role of JAK-STAT signaling within the CNS

JAK-STAT is an efficient and highly regulated system mainly dedicated to the regulation of gene expression. Primarily identified as functioning in hematopoietic cells, its role has been found critical in all cell types, including neurons. This review will focus on JAK-STAT functions in the mature ce...

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Autores principales: Nicolas, Celine S., Amici, Mascia, Bortolotto, Zuner A., Doherty, Andrew, Csaba, Zsolt, Fafouri, Assia, Dournaud, Pascal, Gressens, Pierre, Collingridge, Graham L., Peineau, Stephane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670265/
https://www.ncbi.nlm.nih.gov/pubmed/24058789
http://dx.doi.org/10.4161/jkst.22925
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author Nicolas, Celine S.
Amici, Mascia
Bortolotto, Zuner A.
Doherty, Andrew
Csaba, Zsolt
Fafouri, Assia
Dournaud, Pascal
Gressens, Pierre
Collingridge, Graham L.
Peineau, Stephane
author_facet Nicolas, Celine S.
Amici, Mascia
Bortolotto, Zuner A.
Doherty, Andrew
Csaba, Zsolt
Fafouri, Assia
Dournaud, Pascal
Gressens, Pierre
Collingridge, Graham L.
Peineau, Stephane
author_sort Nicolas, Celine S.
collection PubMed
description JAK-STAT is an efficient and highly regulated system mainly dedicated to the regulation of gene expression. Primarily identified as functioning in hematopoietic cells, its role has been found critical in all cell types, including neurons. This review will focus on JAK-STAT functions in the mature central nervous system. Our recent research suggests the intriguing possibility of a non-nuclear role of STAT3 during synaptic plasticity. Dysregulation of the JAK-STAT pathway in inflammation, cancer and neurodegenerative diseases positions it at the heart of most brain disorders, highlighting the importance to understand how it can influence the fate and functions of brain cells.
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spelling pubmed-36702652013-09-19 The role of JAK-STAT signaling within the CNS Nicolas, Celine S. Amici, Mascia Bortolotto, Zuner A. Doherty, Andrew Csaba, Zsolt Fafouri, Assia Dournaud, Pascal Gressens, Pierre Collingridge, Graham L. Peineau, Stephane JAKSTAT Review JAK-STAT is an efficient and highly regulated system mainly dedicated to the regulation of gene expression. Primarily identified as functioning in hematopoietic cells, its role has been found critical in all cell types, including neurons. This review will focus on JAK-STAT functions in the mature central nervous system. Our recent research suggests the intriguing possibility of a non-nuclear role of STAT3 during synaptic plasticity. Dysregulation of the JAK-STAT pathway in inflammation, cancer and neurodegenerative diseases positions it at the heart of most brain disorders, highlighting the importance to understand how it can influence the fate and functions of brain cells. Landes Bioscience 2013-01-01 2013-01-01 /pmc/articles/PMC3670265/ /pubmed/24058789 http://dx.doi.org/10.4161/jkst.22925 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Nicolas, Celine S.
Amici, Mascia
Bortolotto, Zuner A.
Doherty, Andrew
Csaba, Zsolt
Fafouri, Assia
Dournaud, Pascal
Gressens, Pierre
Collingridge, Graham L.
Peineau, Stephane
The role of JAK-STAT signaling within the CNS
title The role of JAK-STAT signaling within the CNS
title_full The role of JAK-STAT signaling within the CNS
title_fullStr The role of JAK-STAT signaling within the CNS
title_full_unstemmed The role of JAK-STAT signaling within the CNS
title_short The role of JAK-STAT signaling within the CNS
title_sort role of jak-stat signaling within the cns
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670265/
https://www.ncbi.nlm.nih.gov/pubmed/24058789
http://dx.doi.org/10.4161/jkst.22925
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