Interleukin-2 and STAT5 in regulatory T cell development and function

Interleukin-2 and its downstream target STAT5 have effects on many aspects of immune function. This has been perhaps best documented in regulatory T cells. In this review we summarize the initial findings supporting a role for IL2 and STAT5 in regulatory T cell development and outline more recent st...

Descripción completa

Detalles Bibliográficos
Autores principales: Mahmud, Shawn A., Manlove, Luke S., Farrar, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Special Focus Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670270/
https://www.ncbi.nlm.nih.gov/pubmed/24058794
http://dx.doi.org/10.4161/jkst.23154
_version_ 1782271833983156224
author Mahmud, Shawn A.
Manlove, Luke S.
Farrar, Michael A.
author_facet Mahmud, Shawn A.
Manlove, Luke S.
Farrar, Michael A.
author_sort Mahmud, Shawn A.
collection PubMed
description Interleukin-2 and its downstream target STAT5 have effects on many aspects of immune function. This has been perhaps best documented in regulatory T cells. In this review we summarize the initial findings supporting a role for IL2 and STAT5 in regulatory T cell development and outline more recent studies describing how this critical signaling pathway entrains regulatory T cell differentiation and affects regulatory T cell function.
format Online
Article
Text
id pubmed-3670270
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-36702702013-09-19 Interleukin-2 and STAT5 in regulatory T cell development and function Mahmud, Shawn A. Manlove, Luke S. Farrar, Michael A. JAKSTAT Special Focus Review Interleukin-2 and its downstream target STAT5 have effects on many aspects of immune function. This has been perhaps best documented in regulatory T cells. In this review we summarize the initial findings supporting a role for IL2 and STAT5 in regulatory T cell development and outline more recent studies describing how this critical signaling pathway entrains regulatory T cell differentiation and affects regulatory T cell function. Landes Bioscience 2013-01-01 2013-01-01 /pmc/articles/PMC3670270/ /pubmed/24058794 http://dx.doi.org/10.4161/jkst.23154 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Special Focus Review
Mahmud, Shawn A.
Manlove, Luke S.
Farrar, Michael A.
Interleukin-2 and STAT5 in regulatory T cell development and function
title Interleukin-2 and STAT5 in regulatory T cell development and function
title_full Interleukin-2 and STAT5 in regulatory T cell development and function
title_fullStr Interleukin-2 and STAT5 in regulatory T cell development and function
title_full_unstemmed Interleukin-2 and STAT5 in regulatory T cell development and function
title_short Interleukin-2 and STAT5 in regulatory T cell development and function
title_sort interleukin-2 and stat5 in regulatory t cell development and function
topic Special Focus Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670270/
https://www.ncbi.nlm.nih.gov/pubmed/24058794
http://dx.doi.org/10.4161/jkst.23154
work_keys_str_mv AT mahmudshawna interleukin2andstat5inregulatorytcelldevelopmentandfunction
AT manlovelukes interleukin2andstat5inregulatorytcelldevelopmentandfunction
AT farrarmichaela interleukin2andstat5inregulatorytcelldevelopmentandfunction

Ejemplares similares