The STAT3-DNMT1 connection

Gene activity is regulated by transcriptional and epigenetic mechanisms. A paper in 2005 by Zhang et al.(1) showed that STAT3 binds to the DNA methyl transferase, DNMT1 and their data indicated that STAT3 may cause epigenetic gene silencing by targeting DNMT1 to the PTPN6 promoter. Now, a paper by L...

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Detalles Bibliográficos
Autor principal: Thomas, N. Shaun B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670282/
https://www.ncbi.nlm.nih.gov/pubmed/24058781
http://dx.doi.org/10.4161/jkst.22436
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author Thomas, N. Shaun B.
author_facet Thomas, N. Shaun B.
author_sort Thomas, N. Shaun B.
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description Gene activity is regulated by transcriptional and epigenetic mechanisms. A paper in 2005 by Zhang et al.(1) showed that STAT3 binds to the DNA methyl transferase, DNMT1 and their data indicated that STAT3 may cause epigenetic gene silencing by targeting DNMT1 to the PTPN6 promoter. Now, a paper by Lee et al.(2) has fleshed out the mechanism. They provide evidence that acetylation of STAT3 regulates the binding of DNMT1, CpG DNA methylation and regulation of several genes, including that encoding the estrogen receptor α (ESR1) in breast cancer cells.
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spelling pubmed-36702822013-09-19 The STAT3-DNMT1 connection Thomas, N. Shaun B. JAKSTAT Commentary Gene activity is regulated by transcriptional and epigenetic mechanisms. A paper in 2005 by Zhang et al.(1) showed that STAT3 binds to the DNA methyl transferase, DNMT1 and their data indicated that STAT3 may cause epigenetic gene silencing by targeting DNMT1 to the PTPN6 promoter. Now, a paper by Lee et al.(2) has fleshed out the mechanism. They provide evidence that acetylation of STAT3 regulates the binding of DNMT1, CpG DNA methylation and regulation of several genes, including that encoding the estrogen receptor α (ESR1) in breast cancer cells. Landes Bioscience 2012-10-01 2012-10-01 /pmc/articles/PMC3670282/ /pubmed/24058781 http://dx.doi.org/10.4161/jkst.22436 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Commentary
Thomas, N. Shaun B.
The STAT3-DNMT1 connection
title The STAT3-DNMT1 connection
title_full The STAT3-DNMT1 connection
title_fullStr The STAT3-DNMT1 connection
title_full_unstemmed The STAT3-DNMT1 connection
title_short The STAT3-DNMT1 connection
title_sort stat3-dnmt1 connection
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670282/
https://www.ncbi.nlm.nih.gov/pubmed/24058781
http://dx.doi.org/10.4161/jkst.22436
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