JAK-STAT signaling in cardiomyogenesis of cardiac stem cells

Recently various kinds of cardiac stem/progenitor cells have been identified and suggested to be involved in cardiac repair and regeneration in injured myocardium. In this review, we focus on the roles of JAK-STAT signaling in cardiac stem/progenitor cells in cardiomyogenesis. JAK-STAT signaling pla...

Descripción completa

Detalles Bibliográficos
Autores principales: Mohri, Tomomi, Iwakura, Tomohiko, Nakayama, Hiroyuki, Fujio, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670292/
https://www.ncbi.nlm.nih.gov/pubmed/24058761
http://dx.doi.org/10.4161/jkst.20296
_version_ 1782271838723768320
author Mohri, Tomomi
Iwakura, Tomohiko
Nakayama, Hiroyuki
Fujio, Yasushi
author_facet Mohri, Tomomi
Iwakura, Tomohiko
Nakayama, Hiroyuki
Fujio, Yasushi
author_sort Mohri, Tomomi
collection PubMed
description Recently various kinds of cardiac stem/progenitor cells have been identified and suggested to be involved in cardiac repair and regeneration in injured myocardium. In this review, we focus on the roles of JAK-STAT signaling in cardiac stem/progenitor cells in cardiomyogenesis. JAK-STAT signaling plays important roles in the differentiation of stem cells into cardiac lineage cells. The activation of JAK-STAT signal elicits the mobilization of mesenchymal stem cells as well, contributing to the maintenance of cardiac function. Thus we propose that JAK-STAT could be a target signaling pathway in cardiac regenerative therapy.
format Online
Article
Text
id pubmed-3670292
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-36702922013-09-19 JAK-STAT signaling in cardiomyogenesis of cardiac stem cells Mohri, Tomomi Iwakura, Tomohiko Nakayama, Hiroyuki Fujio, Yasushi JAKSTAT Review Recently various kinds of cardiac stem/progenitor cells have been identified and suggested to be involved in cardiac repair and regeneration in injured myocardium. In this review, we focus on the roles of JAK-STAT signaling in cardiac stem/progenitor cells in cardiomyogenesis. JAK-STAT signaling plays important roles in the differentiation of stem cells into cardiac lineage cells. The activation of JAK-STAT signal elicits the mobilization of mesenchymal stem cells as well, contributing to the maintenance of cardiac function. Thus we propose that JAK-STAT could be a target signaling pathway in cardiac regenerative therapy. Landes Bioscience 2012-04-01 /pmc/articles/PMC3670292/ /pubmed/24058761 http://dx.doi.org/10.4161/jkst.20296 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Mohri, Tomomi
Iwakura, Tomohiko
Nakayama, Hiroyuki
Fujio, Yasushi
JAK-STAT signaling in cardiomyogenesis of cardiac stem cells
title JAK-STAT signaling in cardiomyogenesis of cardiac stem cells
title_full JAK-STAT signaling in cardiomyogenesis of cardiac stem cells
title_fullStr JAK-STAT signaling in cardiomyogenesis of cardiac stem cells
title_full_unstemmed JAK-STAT signaling in cardiomyogenesis of cardiac stem cells
title_short JAK-STAT signaling in cardiomyogenesis of cardiac stem cells
title_sort jak-stat signaling in cardiomyogenesis of cardiac stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670292/
https://www.ncbi.nlm.nih.gov/pubmed/24058761
http://dx.doi.org/10.4161/jkst.20296
work_keys_str_mv AT mohritomomi jakstatsignalingincardiomyogenesisofcardiacstemcells
AT iwakuratomohiko jakstatsignalingincardiomyogenesisofcardiacstemcells
AT nakayamahiroyuki jakstatsignalingincardiomyogenesisofcardiacstemcells
AT fujioyasushi jakstatsignalingincardiomyogenesisofcardiacstemcells

Ejemplares similares