Cargando…

Phase I study of tremelimumab (CP-675 206) plus PF-3512676 (CPG 7909) in patients with melanoma or advanced solid tumours

BACKGROUND: Tremelimumab, a fully human cytotoxic T-lymphocyte antigen 4 monoclonal antibody, and PF-3512676, a Toll-like receptor-9 agonist, are targeted immune modulators that elicit durable single-agent antitumour activity in advanced cancer. METHODS: To determine the maximum tolerated dose (MTD)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Millward, M, Underhill, C, Lobb, S, McBurnie, J, Meech, S J, Gomez-Navarro, J, Marshall, M A, Huang, B, Mather, C B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670507/ https://www.ncbi.nlm.nih.gov/pubmed/23652314 http://dx.doi.org/10.1038/bjc.2013.227

Ejemplares similares

Radiosensitization by CpG ODN7909 in an epidermoid laryngeal carcinoma Hep-2 cell line
por: Wang, Shu, et al.
Publicado: (2017)

CpG oligodeoxyribonucleotide 7909 enhances radiosensitivity via downregulating Oct-4 expression in radioresistant lung cancer cells
por: Xing, Na, et al.
Publicado: (2015)

Pitfalls of vaccinations with WT1-, Proteinase3- and MUC1-derived peptides in combination with MontanideISA51 and CpG7909
por: Kuball, Jürgen, et al.
Publicado: (2010)

Impact of CHK2-small interfering RNA on CpG ODN7909-enhanced radiosensitivity in lung cancer A549 cells
por: Chen, Wei, et al.
Publicado: (2012)

Impact on Malaria Parasite Multiplication Rates in Infected Volunteers of the Protein-in-Adjuvant Vaccine AMA1-C1/Alhydrogel+CPG 7909
por: Duncan, Christopher J. A., et al.
Publicado: (2011)

Tremelimumab
Publicado: (2012)

Phase 1 Study in Malaria Naïve Adults of BSAM2/Alhydrogel®+CPG 7909, a Blood Stage Vaccine against P. falciparum Malaria
por: Ellis, Ruth D., et al.
Publicado: (2012)

Phase 1 Trial of AMA1-C1/Alhydrogel plus CPG 7909: An Asexual Blood-Stage Vaccine for Plasmodium falciparum Malaria
por: Mullen, Gregory E. D., et al.
Publicado: (2008)

Preservation of methylated CpG dinucleotides in human CpG islands
por: Panchin, Alexander Y., et al.
Publicado: (2016)

The effect of ataxia-telangiectasia mutated kinase-dependent hyperphosphorylation of checkpoint kinase-2 on oligodeoxynucleotide 7909 containing CpG motifs-enhanced sensitivity to X-rays in human lung adenocarcinoma A549 cells
por: Liu, Xiaoqun, et al.
Publicado: (2015)

The road to ISO 9001:2000
por: McBurnie, DE
Publicado: (2004)

Diagnosis of dermal calcification
por: McBurnie, D
Publicado: (2002)

Phase 1 Trial of the Plasmodium falciparum Blood Stage Vaccine MSP1(42)-C1/Alhydrogel with and without CPG 7909 in Malaria Naïve Adults
por: Ellis, Ruth D., et al.
Publicado: (2010)

Tremelimumab: research and clinical development
por: Comin-Anduix, Begoña, et al.
Publicado: (2016)

Suppressive CpG
por: Van Epps, Heather L.
Publicado: (2005)

Factors to preserve CpG-rich sequences in methylated CpG islands
por: Miyahara, Hiroki, et al.
Publicado: (2015)

Developmental and reproductive safety evaluation of AV7909 anthrax vaccine candidate in rats
por: Mylchreest, Eve, et al.
Publicado: (2020)

High-dose irradiation in combination with toll-like receptor 9 agonist CpG oligodeoxynucleotide 7909 downregulates PD-L1 expression via the NF-κB signaling pathway in non-small cell lung cancer cells
por: Chen, Xue, et al.
Publicado: (2016)

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases
por: Arand, Julia, et al.
Publicado: (2012)

CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function
por: Jang, Hyun Sik, et al.
Publicado: (2017)

Prediction of CpG-island function: CpG clustering vs. sliding-window methods
por: Hackenberg, Michael, et al.
Publicado: (2010)

CpG Methylation Altered the Stability and Structure of the i-Motifs Located in the CpG Islands
por: Oshikawa, Daiki, et al.
Publicado: (2022)

Methyl CpG binding protein 2 (MeCP2) enhances photodimer formation at methyl-CpG sites but suppresses dimer deamination
por: Cannistraro, Vincent J., et al.
Publicado: (2010)

CpGIF: an algorithm for the identification of CpG islands
por: Sujuan, Ye, et al.
Publicado: (2008)

The Effects of O(6)-methyl Guanine DNA-methyl Transferase Promotor Methylation and CpG1, CpG2, CpG3 and CpG4 Methylation on Treatment Response and their Prognostic Significance in Patients with Glioblastoma
por: Yildiz, OG, et al.
Publicado: (2020)

CpG DNA analysis of bacterial STDs
por: Singer, Martin, et al.
Publicado: (2015)

The Control Region of Mitochondrial DNA Shows an Unusual CpG and Non-CpG Methylation Pattern
por: Bellizzi, Dina, et al.
Publicado: (2013)

Evaluation of single CpG sites as proxies of CpG island methylation states at the genome scale
por: Barrera, Víctor, et al.
Publicado: (2012)

Low biological fluctuation of mitochondrial CpG and non-CpG methylation at the single-molecule level
por: Goldsmith, Chloe, et al.
Publicado: (2021)

Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites
por: Grandi, Fiorella C., et al.
Publicado: (2015)

Durvalumab plus tremelimumab in unresectable hepatocellular carcinoma
por: Kudo, Masatoshi
Publicado: (2022)

Durvalumab and tremelimumab combination therapy versus durvalumab or tremelimumab monotherapy for patients with solid tumors: A systematic review and meta-analysis
por: Wang, Bi-Cheng, et al.
Publicado: (2020)

Bidding the CpG island goodbye
por: Greally, John M
Publicado: (2013)

CpG oligodeoxynucleotides as mucosal adjuvants
por: Iho, Sumiko, et al.
Publicado: (2015)

CpGPAP: CpG island predictor analysis platform
por: Chuang, Li-Yeh, et al.
Publicado: (2012)

CpG islands or CpG clusters: how to identify functional GC-rich regions in a genome?
por: Han, Leng, et al.
Publicado: (2009)

In silico identification of single nucleotide variations at CpG sites regulating CpG island existence and size
por: Shyamala, Nivas, et al.
Publicado: (2022)

Intragenic CpG Islands and Their Impact on Gene Regulation
por: Cain, James A., et al.
Publicado: (2022)

Training Management of the Elite Adolescent Soccer Player throughout Maturation
por: McBurnie, Alistair J., et al.
Publicado: (2021)

Correction: McBurnie et al. Training Management of the Elite Adolescent Soccer Player throughout Maturation. Sports 2021, 9, 170
por: McBurnie, Alistair J., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_uu995g3ata1dsaruahdp33bkbd