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Natural Compounds as Regulators of the Cancer Cell Metabolism
Even though altered metabolism is an “old” physiological mechanism, only recently its targeting became a therapeutically interesting strategy and by now it is considered an emerging hallmark of cancer. Nevertheless, a very poor number of compounds are under investigation as potential modulators of c...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670510/ https://www.ncbi.nlm.nih.gov/pubmed/23762063 http://dx.doi.org/10.1155/2013/639401 |
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author | Cerella, Claudia Radogna, Flavia Dicato, Mario Diederich, Marc |
author_facet | Cerella, Claudia Radogna, Flavia Dicato, Mario Diederich, Marc |
author_sort | Cerella, Claudia |
collection | PubMed |
description | Even though altered metabolism is an “old” physiological mechanism, only recently its targeting became a therapeutically interesting strategy and by now it is considered an emerging hallmark of cancer. Nevertheless, a very poor number of compounds are under investigation as potential modulators of cell metabolism. Candidate agents should display selectivity of action towards cancer cells without side effects. This ideal favorable profile would perfectly overlap the requisites of new anticancer therapies and chemopreventive strategies as well. Nature represents a still largely unexplored source of bioactive molecules with a therapeutic potential. Many of these compounds have already been characterized for their multiple anticancer activities. Many of them are absorbed with the diet and therefore possess a known profile in terms of tolerability and bioavailability compared to newly synthetized chemical compounds. The discovery of important cross-talks between mediators of the most therapeutically targeted aberrancies in cancer (i.e., cell proliferation, survival, and migration) and the metabolic machinery allows to predict the possibility that many anticancer activities ascribed to a number of natural compounds may be due, in part, to their ability of modulating metabolic pathways. In this review, we attempt an overview of what is currently known about the potential of natural compounds as modulators of cancer cell metabolism. |
format | Online Article Text |
id | pubmed-3670510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36705102013-06-12 Natural Compounds as Regulators of the Cancer Cell Metabolism Cerella, Claudia Radogna, Flavia Dicato, Mario Diederich, Marc Int J Cell Biol Review Article Even though altered metabolism is an “old” physiological mechanism, only recently its targeting became a therapeutically interesting strategy and by now it is considered an emerging hallmark of cancer. Nevertheless, a very poor number of compounds are under investigation as potential modulators of cell metabolism. Candidate agents should display selectivity of action towards cancer cells without side effects. This ideal favorable profile would perfectly overlap the requisites of new anticancer therapies and chemopreventive strategies as well. Nature represents a still largely unexplored source of bioactive molecules with a therapeutic potential. Many of these compounds have already been characterized for their multiple anticancer activities. Many of them are absorbed with the diet and therefore possess a known profile in terms of tolerability and bioavailability compared to newly synthetized chemical compounds. The discovery of important cross-talks between mediators of the most therapeutically targeted aberrancies in cancer (i.e., cell proliferation, survival, and migration) and the metabolic machinery allows to predict the possibility that many anticancer activities ascribed to a number of natural compounds may be due, in part, to their ability of modulating metabolic pathways. In this review, we attempt an overview of what is currently known about the potential of natural compounds as modulators of cancer cell metabolism. Hindawi Publishing Corporation 2013 2013-05-16 /pmc/articles/PMC3670510/ /pubmed/23762063 http://dx.doi.org/10.1155/2013/639401 Text en Copyright © 2013 Claudia Cerella et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Cerella, Claudia Radogna, Flavia Dicato, Mario Diederich, Marc Natural Compounds as Regulators of the Cancer Cell Metabolism |
title | Natural Compounds as Regulators of the Cancer Cell Metabolism |
title_full | Natural Compounds as Regulators of the Cancer Cell Metabolism |
title_fullStr | Natural Compounds as Regulators of the Cancer Cell Metabolism |
title_full_unstemmed | Natural Compounds as Regulators of the Cancer Cell Metabolism |
title_short | Natural Compounds as Regulators of the Cancer Cell Metabolism |
title_sort | natural compounds as regulators of the cancer cell metabolism |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670510/ https://www.ncbi.nlm.nih.gov/pubmed/23762063 http://dx.doi.org/10.1155/2013/639401 |
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