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Natural Compounds as Regulators of the Cancer Cell Metabolism

Even though altered metabolism is an “old” physiological mechanism, only recently its targeting became a therapeutically interesting strategy and by now it is considered an emerging hallmark of cancer. Nevertheless, a very poor number of compounds are under investigation as potential modulators of c...

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Detalles Bibliográficos
Autores principales: Cerella, Claudia, Radogna, Flavia, Dicato, Mario, Diederich, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670510/
https://www.ncbi.nlm.nih.gov/pubmed/23762063
http://dx.doi.org/10.1155/2013/639401
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author Cerella, Claudia
Radogna, Flavia
Dicato, Mario
Diederich, Marc
author_facet Cerella, Claudia
Radogna, Flavia
Dicato, Mario
Diederich, Marc
author_sort Cerella, Claudia
collection PubMed
description Even though altered metabolism is an “old” physiological mechanism, only recently its targeting became a therapeutically interesting strategy and by now it is considered an emerging hallmark of cancer. Nevertheless, a very poor number of compounds are under investigation as potential modulators of cell metabolism. Candidate agents should display selectivity of action towards cancer cells without side effects. This ideal favorable profile would perfectly overlap the requisites of new anticancer therapies and chemopreventive strategies as well. Nature represents a still largely unexplored source of bioactive molecules with a therapeutic potential. Many of these compounds have already been characterized for their multiple anticancer activities. Many of them are absorbed with the diet and therefore possess a known profile in terms of tolerability and bioavailability compared to newly synthetized chemical compounds. The discovery of important cross-talks between mediators of the most therapeutically targeted aberrancies in cancer (i.e., cell proliferation, survival, and migration) and the metabolic machinery allows to predict the possibility that many anticancer activities ascribed to a number of natural compounds may be due, in part, to their ability of modulating metabolic pathways. In this review, we attempt an overview of what is currently known about the potential of natural compounds as modulators of cancer cell metabolism.
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spelling pubmed-36705102013-06-12 Natural Compounds as Regulators of the Cancer Cell Metabolism Cerella, Claudia Radogna, Flavia Dicato, Mario Diederich, Marc Int J Cell Biol Review Article Even though altered metabolism is an “old” physiological mechanism, only recently its targeting became a therapeutically interesting strategy and by now it is considered an emerging hallmark of cancer. Nevertheless, a very poor number of compounds are under investigation as potential modulators of cell metabolism. Candidate agents should display selectivity of action towards cancer cells without side effects. This ideal favorable profile would perfectly overlap the requisites of new anticancer therapies and chemopreventive strategies as well. Nature represents a still largely unexplored source of bioactive molecules with a therapeutic potential. Many of these compounds have already been characterized for their multiple anticancer activities. Many of them are absorbed with the diet and therefore possess a known profile in terms of tolerability and bioavailability compared to newly synthetized chemical compounds. The discovery of important cross-talks between mediators of the most therapeutically targeted aberrancies in cancer (i.e., cell proliferation, survival, and migration) and the metabolic machinery allows to predict the possibility that many anticancer activities ascribed to a number of natural compounds may be due, in part, to their ability of modulating metabolic pathways. In this review, we attempt an overview of what is currently known about the potential of natural compounds as modulators of cancer cell metabolism. Hindawi Publishing Corporation 2013 2013-05-16 /pmc/articles/PMC3670510/ /pubmed/23762063 http://dx.doi.org/10.1155/2013/639401 Text en Copyright © 2013 Claudia Cerella et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cerella, Claudia
Radogna, Flavia
Dicato, Mario
Diederich, Marc
Natural Compounds as Regulators of the Cancer Cell Metabolism
title Natural Compounds as Regulators of the Cancer Cell Metabolism
title_full Natural Compounds as Regulators of the Cancer Cell Metabolism
title_fullStr Natural Compounds as Regulators of the Cancer Cell Metabolism
title_full_unstemmed Natural Compounds as Regulators of the Cancer Cell Metabolism
title_short Natural Compounds as Regulators of the Cancer Cell Metabolism
title_sort natural compounds as regulators of the cancer cell metabolism
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670510/
https://www.ncbi.nlm.nih.gov/pubmed/23762063
http://dx.doi.org/10.1155/2013/639401
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