Cargando…
Evaluation of the Wound Healing Potential of Resina Draconis (Dracaena cochinchinensis) in Animal Models
Resina Draconis (RD) is a type of dragon's blood resin obtained from Dracaena cochinchinensis (Lour.) S.C. Chen (Yunnan, China). It has been used as a medicine since ancient times by many cultures. The ethanolic extract of Resina Draconis (RDEE) was evaluated for its wound-healing activity usin...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670512/ https://www.ncbi.nlm.nih.gov/pubmed/23762154 http://dx.doi.org/10.1155/2013/709865 |
_version_ | 1782271862376497152 |
---|---|
author | Liu, Huihui Lin, Shaohui Xiao, Dan Zheng, Xiao Gu, Yan Guo, Shanyu |
author_facet | Liu, Huihui Lin, Shaohui Xiao, Dan Zheng, Xiao Gu, Yan Guo, Shanyu |
author_sort | Liu, Huihui |
collection | PubMed |
description | Resina Draconis (RD) is a type of dragon's blood resin obtained from Dracaena cochinchinensis (Lour.) S.C. Chen (Yunnan, China). It has been used as a medicine since ancient times by many cultures. The ethanolic extract of Resina Draconis (RDEE) was evaluated for its wound-healing activity using excision and incision wound models in rats. Group I, the control group, was treated with ointment base. Group II, which served as a reference standard, was treated with moist exposed burn ointment (MEBO). Group III was treated with RDEE. The parameters observed were percentage of wound contraction, epithelialization period, tensile strength, histopathological studies, microvessel density (MVD), and the expression of vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1). The group treated with RDEE showed significantly better wound contraction and better skin-breaking strength as compared with the control group. The results of histopathological examination, MVD, and the expression levels of growth factors supported the outcome of the wound models as well. The present study provided a scientific rationale for the traditional use of RD in the management of wounds. |
format | Online Article Text |
id | pubmed-3670512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36705122013-06-12 Evaluation of the Wound Healing Potential of Resina Draconis (Dracaena cochinchinensis) in Animal Models Liu, Huihui Lin, Shaohui Xiao, Dan Zheng, Xiao Gu, Yan Guo, Shanyu Evid Based Complement Alternat Med Research Article Resina Draconis (RD) is a type of dragon's blood resin obtained from Dracaena cochinchinensis (Lour.) S.C. Chen (Yunnan, China). It has been used as a medicine since ancient times by many cultures. The ethanolic extract of Resina Draconis (RDEE) was evaluated for its wound-healing activity using excision and incision wound models in rats. Group I, the control group, was treated with ointment base. Group II, which served as a reference standard, was treated with moist exposed burn ointment (MEBO). Group III was treated with RDEE. The parameters observed were percentage of wound contraction, epithelialization period, tensile strength, histopathological studies, microvessel density (MVD), and the expression of vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1). The group treated with RDEE showed significantly better wound contraction and better skin-breaking strength as compared with the control group. The results of histopathological examination, MVD, and the expression levels of growth factors supported the outcome of the wound models as well. The present study provided a scientific rationale for the traditional use of RD in the management of wounds. Hindawi Publishing Corporation 2013 2013-05-16 /pmc/articles/PMC3670512/ /pubmed/23762154 http://dx.doi.org/10.1155/2013/709865 Text en Copyright © 2013 Huihui Liu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Liu, Huihui Lin, Shaohui Xiao, Dan Zheng, Xiao Gu, Yan Guo, Shanyu Evaluation of the Wound Healing Potential of Resina Draconis (Dracaena cochinchinensis) in Animal Models |
title | Evaluation of the Wound Healing Potential of Resina Draconis (Dracaena cochinchinensis) in Animal Models |
title_full | Evaluation of the Wound Healing Potential of Resina Draconis (Dracaena cochinchinensis) in Animal Models |
title_fullStr | Evaluation of the Wound Healing Potential of Resina Draconis (Dracaena cochinchinensis) in Animal Models |
title_full_unstemmed | Evaluation of the Wound Healing Potential of Resina Draconis (Dracaena cochinchinensis) in Animal Models |
title_short | Evaluation of the Wound Healing Potential of Resina Draconis (Dracaena cochinchinensis) in Animal Models |
title_sort | evaluation of the wound healing potential of resina draconis (dracaena cochinchinensis) in animal models |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670512/ https://www.ncbi.nlm.nih.gov/pubmed/23762154 http://dx.doi.org/10.1155/2013/709865 |
work_keys_str_mv | AT liuhuihui evaluationofthewoundhealingpotentialofresinadraconisdracaenacochinchinensisinanimalmodels AT linshaohui evaluationofthewoundhealingpotentialofresinadraconisdracaenacochinchinensisinanimalmodels AT xiaodan evaluationofthewoundhealingpotentialofresinadraconisdracaenacochinchinensisinanimalmodels AT zhengxiao evaluationofthewoundhealingpotentialofresinadraconisdracaenacochinchinensisinanimalmodels AT guyan evaluationofthewoundhealingpotentialofresinadraconisdracaenacochinchinensisinanimalmodels AT guoshanyu evaluationofthewoundhealingpotentialofresinadraconisdracaenacochinchinensisinanimalmodels |