Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant

Several neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Bersani, Giuseppe, Marino, Pietropaolo, Valeriani, Giuseppe, Cuoco, Valentina, Zitelli, Claudia, Melcore, Claudia, Bersani, Francesco Saverio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670546/
https://www.ncbi.nlm.nih.gov/pubmed/23762723
http://dx.doi.org/10.1155/2013/926395
_version_ 1782271869989158912
author Bersani, Giuseppe
Marino, Pietropaolo
Valeriani, Giuseppe
Cuoco, Valentina
Zitelli, Claudia
Melcore, Claudia
Bersani, Francesco Saverio
author_facet Bersani, Giuseppe
Marino, Pietropaolo
Valeriani, Giuseppe
Cuoco, Valentina
Zitelli, Claudia
Melcore, Claudia
Bersani, Francesco Saverio
author_sort Bersani, Giuseppe
collection PubMed
description Several neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant. The use of antipsychotics may improve the severity of symptoms; but in order to obtain a complete remission, the reduction in the dose of tacrolimus, or its replacement with alternative immunosuppressant therapies, is recommended.
format Online
Article
Text
id pubmed-3670546
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-36705462013-06-12 Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant Bersani, Giuseppe Marino, Pietropaolo Valeriani, Giuseppe Cuoco, Valentina Zitelli, Claudia Melcore, Claudia Bersani, Francesco Saverio Case Rep Psychiatry Case Report Several neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant. The use of antipsychotics may improve the severity of symptoms; but in order to obtain a complete remission, the reduction in the dose of tacrolimus, or its replacement with alternative immunosuppressant therapies, is recommended. Hindawi Publishing Corporation 2013 2013-05-16 /pmc/articles/PMC3670546/ /pubmed/23762723 http://dx.doi.org/10.1155/2013/926395 Text en Copyright © 2013 Giuseppe Bersani et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Bersani, Giuseppe
Marino, Pietropaolo
Valeriani, Giuseppe
Cuoco, Valentina
Zitelli, Claudia
Melcore, Claudia
Bersani, Francesco Saverio
Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant
title Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant
title_full Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant
title_fullStr Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant
title_full_unstemmed Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant
title_short Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant
title_sort manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670546/
https://www.ncbi.nlm.nih.gov/pubmed/23762723
http://dx.doi.org/10.1155/2013/926395
work_keys_str_mv AT bersanigiuseppe maniclikepsychosisassociatedwithelevatedtroughtacrolimusbloodconcentrations17yearsafterkidneytransplant
AT marinopietropaolo maniclikepsychosisassociatedwithelevatedtroughtacrolimusbloodconcentrations17yearsafterkidneytransplant
AT valerianigiuseppe maniclikepsychosisassociatedwithelevatedtroughtacrolimusbloodconcentrations17yearsafterkidneytransplant
AT cuocovalentina maniclikepsychosisassociatedwithelevatedtroughtacrolimusbloodconcentrations17yearsafterkidneytransplant
AT zitelliclaudia maniclikepsychosisassociatedwithelevatedtroughtacrolimusbloodconcentrations17yearsafterkidneytransplant
AT melcoreclaudia maniclikepsychosisassociatedwithelevatedtroughtacrolimusbloodconcentrations17yearsafterkidneytransplant
AT bersanifrancescosaverio maniclikepsychosisassociatedwithelevatedtroughtacrolimusbloodconcentrations17yearsafterkidneytransplant

Ejemplares similares