Cargando…
Evaluation of the Potential Sensitization of Chlorogenic Acid: A Meta-Analysis
Chlorogenic acid (CGA) widely exists in many plants, which are used as medicinal substances in traditional Chinese medicine injectables (TCMIs) that have been widely applied in clinical treatments. However, it is still controversial whether CGA is responsible for TCMIs-related hypersensitivity. Seve...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670571/ https://www.ncbi.nlm.nih.gov/pubmed/23762111 http://dx.doi.org/10.1155/2013/208467 |
_version_ | 1782271874100625408 |
---|---|
author | Lin, Mingbao Gong, Wan Chen, Qian Sun, Lijuan Wang, Yingchao Fan, Xiaohui |
author_facet | Lin, Mingbao Gong, Wan Chen, Qian Sun, Lijuan Wang, Yingchao Fan, Xiaohui |
author_sort | Lin, Mingbao |
collection | PubMed |
description | Chlorogenic acid (CGA) widely exists in many plants, which are used as medicinal substances in traditional Chinese medicine injectables (TCMIs) that have been widely applied in clinical treatments. However, it is still controversial whether CGA is responsible for TCMIs-related hypersensitivity. Several studies have been performed to evaluate its potential sensitization property, but the results were inconclusive. Therefore, the aim of this study was to evaluate its potential sensitization systematically using meta-analysis based on data extracted from literatures, searching databases of PubMed, EMBASE, ISI Web of Knowledge, CNKI, VIP, and CHINAINFO from January 1979 to October 2012, a total of 108 articles were retrieved by electronic search strategy, out of which 13 studies met the inclusion criteria. In ASA test, odds ratio of behavior changes was 4.33 (1.62, 11.60), showing significant changes after CGA treatment (P = 0.004). Serum IgG, serum histamine, PLN cellularity, and IgG1 AFCs were significantly enhanced after CGA treatment (P < 0.05). Totally, these results indicated that CGA could induce a positive reaction in potential sensitization, and intravenous administration of it might be a key factor for sensitization triggering, which could at least warrant more careful application of TCMIs containing CGA in clinical practices. |
format | Online Article Text |
id | pubmed-3670571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36705712013-06-12 Evaluation of the Potential Sensitization of Chlorogenic Acid: A Meta-Analysis Lin, Mingbao Gong, Wan Chen, Qian Sun, Lijuan Wang, Yingchao Fan, Xiaohui Evid Based Complement Alternat Med Review Article Chlorogenic acid (CGA) widely exists in many plants, which are used as medicinal substances in traditional Chinese medicine injectables (TCMIs) that have been widely applied in clinical treatments. However, it is still controversial whether CGA is responsible for TCMIs-related hypersensitivity. Several studies have been performed to evaluate its potential sensitization property, but the results were inconclusive. Therefore, the aim of this study was to evaluate its potential sensitization systematically using meta-analysis based on data extracted from literatures, searching databases of PubMed, EMBASE, ISI Web of Knowledge, CNKI, VIP, and CHINAINFO from January 1979 to October 2012, a total of 108 articles were retrieved by electronic search strategy, out of which 13 studies met the inclusion criteria. In ASA test, odds ratio of behavior changes was 4.33 (1.62, 11.60), showing significant changes after CGA treatment (P = 0.004). Serum IgG, serum histamine, PLN cellularity, and IgG1 AFCs were significantly enhanced after CGA treatment (P < 0.05). Totally, these results indicated that CGA could induce a positive reaction in potential sensitization, and intravenous administration of it might be a key factor for sensitization triggering, which could at least warrant more careful application of TCMIs containing CGA in clinical practices. Hindawi Publishing Corporation 2013 2013-05-16 /pmc/articles/PMC3670571/ /pubmed/23762111 http://dx.doi.org/10.1155/2013/208467 Text en Copyright © 2013 Mingbao Lin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lin, Mingbao Gong, Wan Chen, Qian Sun, Lijuan Wang, Yingchao Fan, Xiaohui Evaluation of the Potential Sensitization of Chlorogenic Acid: A Meta-Analysis |
title | Evaluation of the Potential Sensitization of Chlorogenic Acid: A Meta-Analysis |
title_full | Evaluation of the Potential Sensitization of Chlorogenic Acid: A Meta-Analysis |
title_fullStr | Evaluation of the Potential Sensitization of Chlorogenic Acid: A Meta-Analysis |
title_full_unstemmed | Evaluation of the Potential Sensitization of Chlorogenic Acid: A Meta-Analysis |
title_short | Evaluation of the Potential Sensitization of Chlorogenic Acid: A Meta-Analysis |
title_sort | evaluation of the potential sensitization of chlorogenic acid: a meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670571/ https://www.ncbi.nlm.nih.gov/pubmed/23762111 http://dx.doi.org/10.1155/2013/208467 |
work_keys_str_mv | AT linmingbao evaluationofthepotentialsensitizationofchlorogenicacidametaanalysis AT gongwan evaluationofthepotentialsensitizationofchlorogenicacidametaanalysis AT chenqian evaluationofthepotentialsensitizationofchlorogenicacidametaanalysis AT sunlijuan evaluationofthepotentialsensitizationofchlorogenicacidametaanalysis AT wangyingchao evaluationofthepotentialsensitizationofchlorogenicacidametaanalysis AT fanxiaohui evaluationofthepotentialsensitizationofchlorogenicacidametaanalysis |