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Maximum Likelihood Estimation of Frequencies of Known Haplotypes from Pooled Sequence Data
DNA samples are often pooled, either by experimental design or because the sample itself is a mixture. For example, when population allele frequencies are of primary interest, individual samples may be pooled together to lower the cost of sequencing. Alternatively, the sample itself may be a mixture...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670732/ https://www.ncbi.nlm.nih.gov/pubmed/23364324 http://dx.doi.org/10.1093/molbev/mst016 |