Persistent Inflammation and Endothelial Activation in HIV-1 Infected Patients after 12 Years of Antiretroviral Therapy

OBJECTIVE: The study investigated markers of inflammation and endothelial activation in HIV infected patients after 12 years of successful combination antiretroviral treatment (cART). METHODS: Inflammation and endothelial activation were assessed by measuring levels of immunoglobulins, β2-microglobu...

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Autores principales: Rönsholt, Frederikke F., Ullum, Henrik, Katzenstein, Terese L., Gerstoft, Jan, Ostrowski, Sisse R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670840/
https://www.ncbi.nlm.nih.gov/pubmed/23755191
http://dx.doi.org/10.1371/journal.pone.0065182
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author Rönsholt, Frederikke F.
Ullum, Henrik
Katzenstein, Terese L.
Gerstoft, Jan
Ostrowski, Sisse R.
author_facet Rönsholt, Frederikke F.
Ullum, Henrik
Katzenstein, Terese L.
Gerstoft, Jan
Ostrowski, Sisse R.
author_sort Rönsholt, Frederikke F.
collection PubMed
description OBJECTIVE: The study investigated markers of inflammation and endothelial activation in HIV infected patients after 12 years of successful combination antiretroviral treatment (cART). METHODS: Inflammation and endothelial activation were assessed by measuring levels of immunoglobulins, β2-microglobulin, interleukin (IL) 8, tumor necrosis factor α (TNFα), vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (sICAM-1), sE-Selectin, and sP-Selectin. RESULTS: HIV infected patients had higher levels of β2-microglobulin, IL-8, TNFα, and sICAM-1 than uninfected controls, and HIV infected patients lacked correlation between platelet counts and sP-Selectin levels found in uninfected controls. CONCLUSION: Discrete signs of systemic and vascular inflammation persist even after very long term cART.
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spelling pubmed-36708402013-06-10 Persistent Inflammation and Endothelial Activation in HIV-1 Infected Patients after 12 Years of Antiretroviral Therapy Rönsholt, Frederikke F. Ullum, Henrik Katzenstein, Terese L. Gerstoft, Jan Ostrowski, Sisse R. PLoS One Research Article OBJECTIVE: The study investigated markers of inflammation and endothelial activation in HIV infected patients after 12 years of successful combination antiretroviral treatment (cART). METHODS: Inflammation and endothelial activation were assessed by measuring levels of immunoglobulins, β2-microglobulin, interleukin (IL) 8, tumor necrosis factor α (TNFα), vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (sICAM-1), sE-Selectin, and sP-Selectin. RESULTS: HIV infected patients had higher levels of β2-microglobulin, IL-8, TNFα, and sICAM-1 than uninfected controls, and HIV infected patients lacked correlation between platelet counts and sP-Selectin levels found in uninfected controls. CONCLUSION: Discrete signs of systemic and vascular inflammation persist even after very long term cART. Public Library of Science 2013-06-03 /pmc/articles/PMC3670840/ /pubmed/23755191 http://dx.doi.org/10.1371/journal.pone.0065182 Text en © 2013 Rönsholt et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Rönsholt, Frederikke F.
Ullum, Henrik
Katzenstein, Terese L.
Gerstoft, Jan
Ostrowski, Sisse R.
Persistent Inflammation and Endothelial Activation in HIV-1 Infected Patients after 12 Years of Antiretroviral Therapy
title Persistent Inflammation and Endothelial Activation in HIV-1 Infected Patients after 12 Years of Antiretroviral Therapy
title_full Persistent Inflammation and Endothelial Activation in HIV-1 Infected Patients after 12 Years of Antiretroviral Therapy
title_fullStr Persistent Inflammation and Endothelial Activation in HIV-1 Infected Patients after 12 Years of Antiretroviral Therapy
title_full_unstemmed Persistent Inflammation and Endothelial Activation in HIV-1 Infected Patients after 12 Years of Antiretroviral Therapy
title_short Persistent Inflammation and Endothelial Activation in HIV-1 Infected Patients after 12 Years of Antiretroviral Therapy
title_sort persistent inflammation and endothelial activation in hiv-1 infected patients after 12 years of antiretroviral therapy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670840/
https://www.ncbi.nlm.nih.gov/pubmed/23755191
http://dx.doi.org/10.1371/journal.pone.0065182
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