Central Nervous System Pathology Progresses Independently of KC and CXCR2 in Globoid-Cell Leukodystrophy

Globoid-cell Leukodystrophy (GLD; Krabbe’s disease) is a rapidly progressing inherited demyelinating disease caused by a deficiency of the lysosomal enzyme Galactosylceramidase (GALC). Deficiency of GALC leads to altered catabolism of galactosylceramide and the cytotoxic lipid, galactosylsphingosine...

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Detalles Bibliográficos
Autores principales: Reddy, Adarsh S., Patel, Jigisha R., Vogler, Carole, Klein, Robyn S., Sands, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670857/
https://www.ncbi.nlm.nih.gov/pubmed/23755134
http://dx.doi.org/10.1371/journal.pone.0064647

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