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Correlation between the molecular subtype of breast cancer and the in vitro adenosine triphosphate-based chemosensitivity assay

PURPOSE: The empirical use of a chemotherapy regimen shows different results in individual breast cancer patient treatment. Recent studies showed the effectiveness of the adenosine triphosphate-based chemotherapy response assay (ATP-CRA). However, little is known about the correlation between chemos...

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Autores principales: Chang, Jina, Lee, Anbok, Lee, Jihyun, Lim, Woosung, Sung, Sun Hee, Moon, Byung-In
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Surgical Society 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670999/
https://www.ncbi.nlm.nih.gov/pubmed/23741688
http://dx.doi.org/10.4174/jkss.2013.84.6.313
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author Chang, Jina
Lee, Anbok
Lee, Jihyun
Lim, Woosung
Sung, Sun Hee
Moon, Byung-In
author_facet Chang, Jina
Lee, Anbok
Lee, Jihyun
Lim, Woosung
Sung, Sun Hee
Moon, Byung-In
author_sort Chang, Jina
collection PubMed
description PURPOSE: The empirical use of a chemotherapy regimen shows different results in individual breast cancer patient treatment. Recent studies showed the effectiveness of the adenosine triphosphate-based chemotherapy response assay (ATP-CRA). However, little is known about the correlation between chemosensitivity and breast cancer molecular subtypes. Therefore, we investigated whether the result of ATP-CRA is associated with a molecular subtype of breast cancer. METHODS: Two hundred eighty-seven patients diagnosed with breast cancer and receiving ATP-CRA at Mokdong Hospital, Ewha Womans University between September 2007 and December 2010 were enrolled in this study. Hormone receptor status, HER2/neu expression, and results of chemosensitivity tests of the patients was analyzed. RESULTS: In all of four subtypes, the combination of two agents showed significant higher mean cell death rate than a single agent. Within the breast cancer cell lines in this study, the range of chemosensitivity response was very wide and varied for each patient. For this reason, the molecular subtype of breast cancer is inconclusive in choosing an effective chemotherapeutic agent and in vitro chemosensitivity test, prior to therapy, could be a useful method for planning chemotherapy for each patient. CONCLUSION: Chemosensitivity response to anticancer agents was found to vary depending on the individual breast cancer patients. The molecular subtype of breast cancer is inconclusive to choose the effective chemotherapeutic agent and the in vitro chemosensitivity test, prior to therapy, could be more useful for planning chemotherapy for each patient.
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spelling pubmed-36709992013-06-05 Correlation between the molecular subtype of breast cancer and the in vitro adenosine triphosphate-based chemosensitivity assay Chang, Jina Lee, Anbok Lee, Jihyun Lim, Woosung Sung, Sun Hee Moon, Byung-In J Korean Surg Soc Original Article PURPOSE: The empirical use of a chemotherapy regimen shows different results in individual breast cancer patient treatment. Recent studies showed the effectiveness of the adenosine triphosphate-based chemotherapy response assay (ATP-CRA). However, little is known about the correlation between chemosensitivity and breast cancer molecular subtypes. Therefore, we investigated whether the result of ATP-CRA is associated with a molecular subtype of breast cancer. METHODS: Two hundred eighty-seven patients diagnosed with breast cancer and receiving ATP-CRA at Mokdong Hospital, Ewha Womans University between September 2007 and December 2010 were enrolled in this study. Hormone receptor status, HER2/neu expression, and results of chemosensitivity tests of the patients was analyzed. RESULTS: In all of four subtypes, the combination of two agents showed significant higher mean cell death rate than a single agent. Within the breast cancer cell lines in this study, the range of chemosensitivity response was very wide and varied for each patient. For this reason, the molecular subtype of breast cancer is inconclusive in choosing an effective chemotherapeutic agent and in vitro chemosensitivity test, prior to therapy, could be a useful method for planning chemotherapy for each patient. CONCLUSION: Chemosensitivity response to anticancer agents was found to vary depending on the individual breast cancer patients. The molecular subtype of breast cancer is inconclusive to choose the effective chemotherapeutic agent and the in vitro chemosensitivity test, prior to therapy, could be more useful for planning chemotherapy for each patient. The Korean Surgical Society 2013-06 2013-05-28 /pmc/articles/PMC3670999/ /pubmed/23741688 http://dx.doi.org/10.4174/jkss.2013.84.6.313 Text en Copyright © 2013, the Korean Surgical Society http://creativecommons.org/licenses/by-nc/3.0/ Journal of the Korean Surgical Society is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chang, Jina
Lee, Anbok
Lee, Jihyun
Lim, Woosung
Sung, Sun Hee
Moon, Byung-In
Correlation between the molecular subtype of breast cancer and the in vitro adenosine triphosphate-based chemosensitivity assay
title Correlation between the molecular subtype of breast cancer and the in vitro adenosine triphosphate-based chemosensitivity assay
title_full Correlation between the molecular subtype of breast cancer and the in vitro adenosine triphosphate-based chemosensitivity assay
title_fullStr Correlation between the molecular subtype of breast cancer and the in vitro adenosine triphosphate-based chemosensitivity assay
title_full_unstemmed Correlation between the molecular subtype of breast cancer and the in vitro adenosine triphosphate-based chemosensitivity assay
title_short Correlation between the molecular subtype of breast cancer and the in vitro adenosine triphosphate-based chemosensitivity assay
title_sort correlation between the molecular subtype of breast cancer and the in vitro adenosine triphosphate-based chemosensitivity assay
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670999/
https://www.ncbi.nlm.nih.gov/pubmed/23741688
http://dx.doi.org/10.4174/jkss.2013.84.6.313
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