LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

BACKGROUND: LEDGINs are novel allosteric HIV integrase (IN) inhibitors that target the lens epithelium-derived growth factor (LEDGF)/p75 binding pocket of IN. They block HIV-1 integration by abrogating the interaction between LEDGF/p75 and IN as well as by allosterically inhibiting the catalytic act...

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Detalles Bibliográficos
Autores principales: Desimmie, Belete Ayele, Schrijvers, Rik, Demeulemeester, Jonas, Borrenberghs, Doortje, Weydert, Caroline, Thys, Wannes, Vets, Sofie, Van Remoortel, Barbara, Hofkens, Johan, De Rijck, Jan, Hendrix, Jelle, Bannert, Norbert, Gijsbers, Rik, Christ, Frauke, Debyser, Zeger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671127/
https://www.ncbi.nlm.nih.gov/pubmed/23721378
http://dx.doi.org/10.1186/1742-4690-10-57

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