Non-steroidal anti-inflammatory drugs activate NADPH oxidase in adipocytes and raise the H(2)O(2) pool to prevent cAMP-stimulated protein kinase a activation and inhibit lipolysis

BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) —aspirin, naproxen, nimesulide, and piroxicam— lowered activation of type II cAMP-dependent protein kinase A (PKA-II) in isolated rat adipocytes, decreasing adrenaline- and dibutyryl cAMP (Bt(2)cAMP)-stimulated lipolysis. The molecular bases...

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Detalles Bibliográficos
Autores principales: Vázquez-Meza, Héctor, de Piña, Martha Zentella, Pardo, Juan Pablo, Riveros-Rosas, Héctor, Villalobos-Molina, Rafael, Piña, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671242/
https://www.ncbi.nlm.nih.gov/pubmed/23718778
http://dx.doi.org/10.1186/1471-2091-14-13

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