miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1

MicroRNAs (miRNAs) have been implied to play crucial roles for epithelial-to-mesenchymal transition (EMT) of non-small-cell lung cancer cells (NSCLC cells). Here we found that the expression of miR-149, downregulated in lung cancer, was inversely correlated with invasive capability and the EMT pheno...

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Detalles Bibliográficos
Autores principales: Ke, Yang, Zhao, Weiyong, Xiong, Jie, Cao, Rubo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671264/
https://www.ncbi.nlm.nih.gov/pubmed/23762558
http://dx.doi.org/10.1155/2013/506731
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author Ke, Yang
Zhao, Weiyong
Xiong, Jie
Cao, Rubo
author_facet Ke, Yang
Zhao, Weiyong
Xiong, Jie
Cao, Rubo
author_sort Ke, Yang
collection PubMed
description MicroRNAs (miRNAs) have been implied to play crucial roles for epithelial-to-mesenchymal transition (EMT) of non-small-cell lung cancer cells (NSCLC cells). Here we found that the expression of miR-149, downregulated in lung cancer, was inversely correlated with invasive capability and the EMT phenotype of NSCLC cells. miR-149 inhibited EMT in NSCLC cells. Furthermore, we demonstrated that miR-149 directly targeted Forkhead box M1 (FOXM1), and FOXM1 was involved in the EMT induced by TGF-β1 in A549 cells. Overexpression of FOXM1 restored EMT process inhibited by miR-149. Our work suggested that miR-149 might be an EMT suppressor in NSCLC cells.
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spelling pubmed-36712642013-06-12 miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1 Ke, Yang Zhao, Weiyong Xiong, Jie Cao, Rubo Biochem Res Int Research Article MicroRNAs (miRNAs) have been implied to play crucial roles for epithelial-to-mesenchymal transition (EMT) of non-small-cell lung cancer cells (NSCLC cells). Here we found that the expression of miR-149, downregulated in lung cancer, was inversely correlated with invasive capability and the EMT phenotype of NSCLC cells. miR-149 inhibited EMT in NSCLC cells. Furthermore, we demonstrated that miR-149 directly targeted Forkhead box M1 (FOXM1), and FOXM1 was involved in the EMT induced by TGF-β1 in A549 cells. Overexpression of FOXM1 restored EMT process inhibited by miR-149. Our work suggested that miR-149 might be an EMT suppressor in NSCLC cells. Hindawi Publishing Corporation 2013 2013-05-16 /pmc/articles/PMC3671264/ /pubmed/23762558 http://dx.doi.org/10.1155/2013/506731 Text en Copyright © 2013 Yang Ke et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ke, Yang
Zhao, Weiyong
Xiong, Jie
Cao, Rubo
miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1
title miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1
title_full miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1
title_fullStr miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1
title_full_unstemmed miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1
title_short miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1
title_sort mir-149 inhibits non-small-cell lung cancer cells emt by targeting foxm1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671264/
https://www.ncbi.nlm.nih.gov/pubmed/23762558
http://dx.doi.org/10.1155/2013/506731
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