The P66Shc/Mitochondrial Permeability Transition Pore Pathway Determines Neurodegeneration

Mitochondrial-mediated oxidative stress and apoptosis play a crucial role in neurodegenerative disease and aging. Both mitochondrial permeability transition (PT) and swelling of mitochondria have been involved in neurodegeneration. Indeed, knockout mice for cyclophilin-D (Cyc-D), a key regulatory co...

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Detalles Bibliográficos
Autores principales: Savino, Costanza, Pelicci, PierGiuseppe, Giorgio, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671270/
https://www.ncbi.nlm.nih.gov/pubmed/23766859
http://dx.doi.org/10.1155/2013/719407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671270/
https://www.ncbi.nlm.nih.gov/pubmed/23766859
http://dx.doi.org/10.1155/2013/719407

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