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The P66Shc/Mitochondrial Permeability Transition Pore Pathway Determines Neurodegeneration

Mitochondrial-mediated oxidative stress and apoptosis play a crucial role in neurodegenerative disease and aging. Both mitochondrial permeability transition (PT) and swelling of mitochondria have been involved in neurodegeneration. Indeed, knockout mice for cyclophilin-D (Cyc-D), a key regulatory co...

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Detalles Bibliográficos
Autores principales:	Savino, Costanza, Pelicci, PierGiuseppe, Giorgio, Marco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671270/ https://www.ncbi.nlm.nih.gov/pubmed/23766859 http://dx.doi.org/10.1155/2013/719407

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