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Dendritic Cells: Cellular Mediators for Immunological Tolerance

In general, immunological tolerance is acquired upon treatment with non-specific immunosuppressive drugs. This indiscriminate immunosuppression of the patient often causes serious side-effects, such as opportunistic infectious diseases. Therefore, the need for antigen-specific modulation of pathogen...

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Autores principales: Chung, Chun Yuen J., Ysebaert, Dirk, Berneman, Zwi N., Cools, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671285/
https://www.ncbi.nlm.nih.gov/pubmed/23762100
http://dx.doi.org/10.1155/2013/972865
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author Chung, Chun Yuen J.
Ysebaert, Dirk
Berneman, Zwi N.
Cools, Nathalie
author_facet Chung, Chun Yuen J.
Ysebaert, Dirk
Berneman, Zwi N.
Cools, Nathalie
author_sort Chung, Chun Yuen J.
collection PubMed
description In general, immunological tolerance is acquired upon treatment with non-specific immunosuppressive drugs. This indiscriminate immunosuppression of the patient often causes serious side-effects, such as opportunistic infectious diseases. Therefore, the need for antigen-specific modulation of pathogenic immune responses is of crucial importance in the treatment of inflammatory diseases. In this perspective, dendritic cells (DCs) can have an important immune-regulatory function, besides their notorious antigen-presenting capacity. DCs appear to be essential for both central and peripheral tolerance. In the thymus, DCs are involved in clonal deletion of autoreactive immature T cells by presenting self-antigens. Additionally, tolerance is achieved by their interactions with T cells in the periphery and subsequent induction of T cell anergy, T cell deletion, and induction of regulatory T cells (Treg). Various studies have described, modulation of DC characteristics with the purpose to induce antigen-specific tolerance in autoimmune diseases, graft-versus-host-disease (GVHD), and transplantations. Promising results in animal models have prompted researchers to initiate first-in-men clinical trials. The purpose of current review is to provide an overview of the role of DCs in the immunopathogenesis of autoimmunity, as well as recent concepts of dendritic cell-based therapeutic opportunities in autoimmune diseases.
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spelling pubmed-36712852013-06-12 Dendritic Cells: Cellular Mediators for Immunological Tolerance Chung, Chun Yuen J. Ysebaert, Dirk Berneman, Zwi N. Cools, Nathalie Clin Dev Immunol Review Article In general, immunological tolerance is acquired upon treatment with non-specific immunosuppressive drugs. This indiscriminate immunosuppression of the patient often causes serious side-effects, such as opportunistic infectious diseases. Therefore, the need for antigen-specific modulation of pathogenic immune responses is of crucial importance in the treatment of inflammatory diseases. In this perspective, dendritic cells (DCs) can have an important immune-regulatory function, besides their notorious antigen-presenting capacity. DCs appear to be essential for both central and peripheral tolerance. In the thymus, DCs are involved in clonal deletion of autoreactive immature T cells by presenting self-antigens. Additionally, tolerance is achieved by their interactions with T cells in the periphery and subsequent induction of T cell anergy, T cell deletion, and induction of regulatory T cells (Treg). Various studies have described, modulation of DC characteristics with the purpose to induce antigen-specific tolerance in autoimmune diseases, graft-versus-host-disease (GVHD), and transplantations. Promising results in animal models have prompted researchers to initiate first-in-men clinical trials. The purpose of current review is to provide an overview of the role of DCs in the immunopathogenesis of autoimmunity, as well as recent concepts of dendritic cell-based therapeutic opportunities in autoimmune diseases. Hindawi Publishing Corporation 2013 2013-05-15 /pmc/articles/PMC3671285/ /pubmed/23762100 http://dx.doi.org/10.1155/2013/972865 Text en Copyright © 2013 Chun Yuen J. Chung et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chung, Chun Yuen J.
Ysebaert, Dirk
Berneman, Zwi N.
Cools, Nathalie
Dendritic Cells: Cellular Mediators for Immunological Tolerance
title Dendritic Cells: Cellular Mediators for Immunological Tolerance
title_full Dendritic Cells: Cellular Mediators for Immunological Tolerance
title_fullStr Dendritic Cells: Cellular Mediators for Immunological Tolerance
title_full_unstemmed Dendritic Cells: Cellular Mediators for Immunological Tolerance
title_short Dendritic Cells: Cellular Mediators for Immunological Tolerance
title_sort dendritic cells: cellular mediators for immunological tolerance
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671285/
https://www.ncbi.nlm.nih.gov/pubmed/23762100
http://dx.doi.org/10.1155/2013/972865
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