Cargando…

ESF-EMBO Symposium “Molecular Biology and Innovative Therapies in Sarcomas of Childhood and Adolescence” Sept 29–Oct 4, Polonia Castle Pultusk, Poland

Rhabdomyosarcoma (RMS) and Ewing sarcoma (ES) are among the most common pediatric sarcomas (Arndt et al., 2012). Despite sarcomas representing a highly heterogeneous group of tumors, ES and alveolar RMS (ARMS) typically share one common genetic characteristic, namely a specific chromosomal transloca...

Descripción completa

Detalles Bibliográficos
Autores principales: Schäfer, Beat W., Koscielniak, Ewa, Kovar, Heinrich, Fulda, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671287/
https://www.ncbi.nlm.nih.gov/pubmed/23761860
http://dx.doi.org/10.3389/fonc.2013.00142
_version_ 1782271962448396288
author Schäfer, Beat W.
Koscielniak, Ewa
Kovar, Heinrich
Fulda, Simone
author_facet Schäfer, Beat W.
Koscielniak, Ewa
Kovar, Heinrich
Fulda, Simone
author_sort Schäfer, Beat W.
collection PubMed
description Rhabdomyosarcoma (RMS) and Ewing sarcoma (ES) are among the most common pediatric sarcomas (Arndt et al., 2012). Despite sarcomas representing a highly heterogeneous group of tumors, ES and alveolar RMS (ARMS) typically share one common genetic characteristic, namely a specific chromosomal translocation (Helman and Meltzer, 2003; Lessnick and Ladanyi, 2012). These translocations generate fusion proteins, which are composed of two transcription factors (TF). Typically, one TF is a developmentally regulated factor that is essential for proper specification of a given lineage and provides the DNA-binding domain, while the partner TF contributes a transactivation domain that drives aberrant expression of target genes. Based on these common genetic characteristics, the first ESF-EMBO research conference entitled “Molecular Biology and Innovative Therapies in Sarcomas of Childhood and Adolescence” with special focus on RMS and ES was held at the Polonia Castle in Pultusk, Poland. The conference gathered 70 participants from more than 15 countries and several continents representing most research groups that are active in this field.
format Online
Article
Text
id pubmed-3671287
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-36712872013-06-11 ESF-EMBO Symposium “Molecular Biology and Innovative Therapies in Sarcomas of Childhood and Adolescence” Sept 29–Oct 4, Polonia Castle Pultusk, Poland Schäfer, Beat W. Koscielniak, Ewa Kovar, Heinrich Fulda, Simone Front Oncol Oncology Rhabdomyosarcoma (RMS) and Ewing sarcoma (ES) are among the most common pediatric sarcomas (Arndt et al., 2012). Despite sarcomas representing a highly heterogeneous group of tumors, ES and alveolar RMS (ARMS) typically share one common genetic characteristic, namely a specific chromosomal translocation (Helman and Meltzer, 2003; Lessnick and Ladanyi, 2012). These translocations generate fusion proteins, which are composed of two transcription factors (TF). Typically, one TF is a developmentally regulated factor that is essential for proper specification of a given lineage and provides the DNA-binding domain, while the partner TF contributes a transactivation domain that drives aberrant expression of target genes. Based on these common genetic characteristics, the first ESF-EMBO research conference entitled “Molecular Biology and Innovative Therapies in Sarcomas of Childhood and Adolescence” with special focus on RMS and ES was held at the Polonia Castle in Pultusk, Poland. The conference gathered 70 participants from more than 15 countries and several continents representing most research groups that are active in this field. Frontiers Media S.A. 2013-06-04 /pmc/articles/PMC3671287/ /pubmed/23761860 http://dx.doi.org/10.3389/fonc.2013.00142 Text en Copyright © 2013 Schäfer, Koscielniak, Kovar and Fulda. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Oncology
Schäfer, Beat W.
Koscielniak, Ewa
Kovar, Heinrich
Fulda, Simone
ESF-EMBO Symposium “Molecular Biology and Innovative Therapies in Sarcomas of Childhood and Adolescence” Sept 29–Oct 4, Polonia Castle Pultusk, Poland
title ESF-EMBO Symposium “Molecular Biology and Innovative Therapies in Sarcomas of Childhood and Adolescence” Sept 29–Oct 4, Polonia Castle Pultusk, Poland
title_full ESF-EMBO Symposium “Molecular Biology and Innovative Therapies in Sarcomas of Childhood and Adolescence” Sept 29–Oct 4, Polonia Castle Pultusk, Poland
title_fullStr ESF-EMBO Symposium “Molecular Biology and Innovative Therapies in Sarcomas of Childhood and Adolescence” Sept 29–Oct 4, Polonia Castle Pultusk, Poland
title_full_unstemmed ESF-EMBO Symposium “Molecular Biology and Innovative Therapies in Sarcomas of Childhood and Adolescence” Sept 29–Oct 4, Polonia Castle Pultusk, Poland
title_short ESF-EMBO Symposium “Molecular Biology and Innovative Therapies in Sarcomas of Childhood and Adolescence” Sept 29–Oct 4, Polonia Castle Pultusk, Poland
title_sort esf-embo symposium “molecular biology and innovative therapies in sarcomas of childhood and adolescence” sept 29–oct 4, polonia castle pultusk, poland
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671287/
https://www.ncbi.nlm.nih.gov/pubmed/23761860
http://dx.doi.org/10.3389/fonc.2013.00142
work_keys_str_mv AT schaferbeatw esfembosymposiummolecularbiologyandinnovativetherapiesinsarcomasofchildhoodandadolescencesept29oct4poloniacastlepultuskpoland
AT koscielniakewa esfembosymposiummolecularbiologyandinnovativetherapiesinsarcomasofchildhoodandadolescencesept29oct4poloniacastlepultuskpoland
AT kovarheinrich esfembosymposiummolecularbiologyandinnovativetherapiesinsarcomasofchildhoodandadolescencesept29oct4poloniacastlepultuskpoland
AT fuldasimone esfembosymposiummolecularbiologyandinnovativetherapiesinsarcomasofchildhoodandadolescencesept29oct4poloniacastlepultuskpoland