The Janus Head of T Cell Aging – Autoimmunity and Immunodeficiency

Immune aging is best known for its immune defects that increase susceptibility to infections and reduce adaptive immune responses to vaccination. In parallel, the aged immune system is prone to autoimmune responses and many autoimmune diseases increase in incidence with age or are even preferentiall...

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Autores principales: Goronzy, Jörg J., Li, Guangjin, Yang, Zhen, Weyand, Cornelia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671290/
https://www.ncbi.nlm.nih.gov/pubmed/23761790
http://dx.doi.org/10.3389/fimmu.2013.00131
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author Goronzy, Jörg J.
Li, Guangjin
Yang, Zhen
Weyand, Cornelia M.
author_facet Goronzy, Jörg J.
Li, Guangjin
Yang, Zhen
Weyand, Cornelia M.
author_sort Goronzy, Jörg J.
collection PubMed
description Immune aging is best known for its immune defects that increase susceptibility to infections and reduce adaptive immune responses to vaccination. In parallel, the aged immune system is prone to autoimmune responses and many autoimmune diseases increase in incidence with age or are even preferentially encountered in the elderly. Why an immune system that suboptimally responds to exogenous antigen fails to maintain tolerance to self-antigens appears to be perplexing. In this review, we will discuss age-associated deviations in the immune repertoire and the regulation of signaling pathways that may shed light on this conundrum.
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spelling pubmed-36712902013-06-11 The Janus Head of T Cell Aging – Autoimmunity and Immunodeficiency Goronzy, Jörg J. Li, Guangjin Yang, Zhen Weyand, Cornelia M. Front Immunol Immunology Immune aging is best known for its immune defects that increase susceptibility to infections and reduce adaptive immune responses to vaccination. In parallel, the aged immune system is prone to autoimmune responses and many autoimmune diseases increase in incidence with age or are even preferentially encountered in the elderly. Why an immune system that suboptimally responds to exogenous antigen fails to maintain tolerance to self-antigens appears to be perplexing. In this review, we will discuss age-associated deviations in the immune repertoire and the regulation of signaling pathways that may shed light on this conundrum. Frontiers Media S.A. 2013-06-04 /pmc/articles/PMC3671290/ /pubmed/23761790 http://dx.doi.org/10.3389/fimmu.2013.00131 Text en Copyright © 2013 Goronzy, Li, Yang and Weyand. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Immunology
Goronzy, Jörg J.
Li, Guangjin
Yang, Zhen
Weyand, Cornelia M.
The Janus Head of T Cell Aging – Autoimmunity and Immunodeficiency
title The Janus Head of T Cell Aging – Autoimmunity and Immunodeficiency
title_full The Janus Head of T Cell Aging – Autoimmunity and Immunodeficiency
title_fullStr The Janus Head of T Cell Aging – Autoimmunity and Immunodeficiency
title_full_unstemmed The Janus Head of T Cell Aging – Autoimmunity and Immunodeficiency
title_short The Janus Head of T Cell Aging – Autoimmunity and Immunodeficiency
title_sort janus head of t cell aging – autoimmunity and immunodeficiency
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671290/
https://www.ncbi.nlm.nih.gov/pubmed/23761790
http://dx.doi.org/10.3389/fimmu.2013.00131
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