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Bilateral Vocal Cord Carcinoma in a Sarcoidosis Patient during Infliximab Therapy

Introduction. Although the role of TNF-α in tumor development is not fully understood, an increased risk of malignancy with TNF-α-inhibitors, such as infliximab, has been suggested. Case Presentation. We present a 54-year-old nonsmoking female sarcoidosis patient. After seven months of infliximab th...

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Autores principales: Vorselaars, Adriane D. M., Sjögren, Elisabeth V., van Moorsel, Coline H. M., Grutters, Jan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671292/
https://www.ncbi.nlm.nih.gov/pubmed/23762724
http://dx.doi.org/10.1155/2013/308092
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author Vorselaars, Adriane D. M.
Sjögren, Elisabeth V.
van Moorsel, Coline H. M.
Grutters, Jan C.
author_facet Vorselaars, Adriane D. M.
Sjögren, Elisabeth V.
van Moorsel, Coline H. M.
Grutters, Jan C.
author_sort Vorselaars, Adriane D. M.
collection PubMed
description Introduction. Although the role of TNF-α in tumor development is not fully understood, an increased risk of malignancy with TNF-α-inhibitors, such as infliximab, has been suggested. Case Presentation. We present a 54-year-old nonsmoking female sarcoidosis patient. After seven months of infliximab therapy a T1aN0M0 larynx carcinoma of the right vocal cord was found and excised. Within a year, whilst still on treatment, a second larynx carcinoma of the opposite vocal cord appeared. Discussion. A bilateral vocal cord tumor is rare, especially in a never smoker. Evidence on the role of infliximab in carcinogenesis is inconclusive. To date, there are no follow-up studies evaluating malignancy risk of infliximab therapy in sarcoidosis patients. No studies in other diseases focus on laryngeal carcinomas during infliximab use. We argue that infliximab treatment might have attributed to the rapid progression of vocal cord carcinomas in this patient with an a priori low risk tumor profile. This case illustrates that caution remains warranted in patients with previous malignancies when considering initiation of TNF-α-inhibitors.
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spelling pubmed-36712922013-06-12 Bilateral Vocal Cord Carcinoma in a Sarcoidosis Patient during Infliximab Therapy Vorselaars, Adriane D. M. Sjögren, Elisabeth V. van Moorsel, Coline H. M. Grutters, Jan C. Case Rep Pulmonol Case Report Introduction. Although the role of TNF-α in tumor development is not fully understood, an increased risk of malignancy with TNF-α-inhibitors, such as infliximab, has been suggested. Case Presentation. We present a 54-year-old nonsmoking female sarcoidosis patient. After seven months of infliximab therapy a T1aN0M0 larynx carcinoma of the right vocal cord was found and excised. Within a year, whilst still on treatment, a second larynx carcinoma of the opposite vocal cord appeared. Discussion. A bilateral vocal cord tumor is rare, especially in a never smoker. Evidence on the role of infliximab in carcinogenesis is inconclusive. To date, there are no follow-up studies evaluating malignancy risk of infliximab therapy in sarcoidosis patients. No studies in other diseases focus on laryngeal carcinomas during infliximab use. We argue that infliximab treatment might have attributed to the rapid progression of vocal cord carcinomas in this patient with an a priori low risk tumor profile. This case illustrates that caution remains warranted in patients with previous malignancies when considering initiation of TNF-α-inhibitors. Hindawi Publishing Corporation 2013 2013-05-15 /pmc/articles/PMC3671292/ /pubmed/23762724 http://dx.doi.org/10.1155/2013/308092 Text en Copyright © 2013 Adriane D. M. Vorselaars et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Vorselaars, Adriane D. M.
Sjögren, Elisabeth V.
van Moorsel, Coline H. M.
Grutters, Jan C.
Bilateral Vocal Cord Carcinoma in a Sarcoidosis Patient during Infliximab Therapy
title Bilateral Vocal Cord Carcinoma in a Sarcoidosis Patient during Infliximab Therapy
title_full Bilateral Vocal Cord Carcinoma in a Sarcoidosis Patient during Infliximab Therapy
title_fullStr Bilateral Vocal Cord Carcinoma in a Sarcoidosis Patient during Infliximab Therapy
title_full_unstemmed Bilateral Vocal Cord Carcinoma in a Sarcoidosis Patient during Infliximab Therapy
title_short Bilateral Vocal Cord Carcinoma in a Sarcoidosis Patient during Infliximab Therapy
title_sort bilateral vocal cord carcinoma in a sarcoidosis patient during infliximab therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671292/
https://www.ncbi.nlm.nih.gov/pubmed/23762724
http://dx.doi.org/10.1155/2013/308092
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