The antimalarial ferroquine: from bench to clinic

Ferroquine (FQ, SSR97193) is currently the most advanced organometallic drug candidate and about to complete phase II clinical trials as a treatment for uncomplicated malaria. This ferrocenecontaining compound is active against both chloroquine-susceptible and chloroquine-resistant Plasmodium falcip...

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Detalles Bibliográficos
Autores principales: Biot, C., Nosten, F., Fraisse, L., Ter-Minassian, D., Khalife, J., Dive, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: EDP Sciences 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671469/
https://www.ncbi.nlm.nih.gov/pubmed/21894260
http://dx.doi.org/10.1051/parasite/2011183207
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author Biot, C.
Nosten, F.
Fraisse, L.
Ter-Minassian, D.
Khalife, J.
Dive, D.
author_facet Biot, C.
Nosten, F.
Fraisse, L.
Ter-Minassian, D.
Khalife, J.
Dive, D.
author_sort Biot, C.
collection PubMed
description Ferroquine (FQ, SSR97193) is currently the most advanced organometallic drug candidate and about to complete phase II clinical trials as a treatment for uncomplicated malaria. This ferrocenecontaining compound is active against both chloroquine-susceptible and chloroquine-resistant Plasmodium falciparum and P. vivax strains and/or isolates. This article focuses on the discovery of FQ, its antimalarial activity, the hypothesis of its mode of action, the current absence of resistance in vitro and recent clinical trials.
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spelling pubmed-36714692013-07-24 The antimalarial ferroquine: from bench to clinic Biot, C. Nosten, F. Fraisse, L. Ter-Minassian, D. Khalife, J. Dive, D. Parasite Review Ferroquine (FQ, SSR97193) is currently the most advanced organometallic drug candidate and about to complete phase II clinical trials as a treatment for uncomplicated malaria. This ferrocenecontaining compound is active against both chloroquine-susceptible and chloroquine-resistant Plasmodium falciparum and P. vivax strains and/or isolates. This article focuses on the discovery of FQ, its antimalarial activity, the hypothesis of its mode of action, the current absence of resistance in vitro and recent clinical trials. EDP Sciences 2011-08 2011-08-15 /pmc/articles/PMC3671469/ /pubmed/21894260 http://dx.doi.org/10.1051/parasite/2011183207 Text en © PRINCEPS Editions, Paris, 2011 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Biot, C.
Nosten, F.
Fraisse, L.
Ter-Minassian, D.
Khalife, J.
Dive, D.
The antimalarial ferroquine: from bench to clinic
title The antimalarial ferroquine: from bench to clinic
title_full The antimalarial ferroquine: from bench to clinic
title_fullStr The antimalarial ferroquine: from bench to clinic
title_full_unstemmed The antimalarial ferroquine: from bench to clinic
title_short The antimalarial ferroquine: from bench to clinic
title_sort antimalarial ferroquine: from bench to clinic
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671469/
https://www.ncbi.nlm.nih.gov/pubmed/21894260
http://dx.doi.org/10.1051/parasite/2011183207
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