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Urea channel inhibitors (UCIs): A new functional class of aquaretics

Using large-scale small molecule screening techniques, Li et al. have identified a compound that inhibits the UT-B urea channel. They propose that this or similar compounds could be used as aquaretic agents to increase water excretion without changes in electrolyte excretion. Such compounds would po...

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Detalles Bibliográficos
Autores principales: Knepper, Mark A., Miranda, Carlos A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671487/
https://www.ncbi.nlm.nih.gov/pubmed/23728001
http://dx.doi.org/10.1038/ki.2013.94
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author Knepper, Mark A.
Miranda, Carlos A.
author_facet Knepper, Mark A.
Miranda, Carlos A.
author_sort Knepper, Mark A.
collection PubMed
description Using large-scale small molecule screening techniques, Li et al. have identified a compound that inhibits the UT-B urea channel. They propose that this or similar compounds could be used as aquaretic agents to increase water excretion without changes in electrolyte excretion. Such compounds would potentially be useful in treatment of hyponatremic disorders. Here we review the physiological basis for the action of urea channel inhibitors in the kidney and assess their clinical potential.
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spelling pubmed-36714872013-12-01 Urea channel inhibitors (UCIs): A new functional class of aquaretics Knepper, Mark A. Miranda, Carlos A. Kidney Int Article Using large-scale small molecule screening techniques, Li et al. have identified a compound that inhibits the UT-B urea channel. They propose that this or similar compounds could be used as aquaretic agents to increase water excretion without changes in electrolyte excretion. Such compounds would potentially be useful in treatment of hyponatremic disorders. Here we review the physiological basis for the action of urea channel inhibitors in the kidney and assess their clinical potential. 2013-06 /pmc/articles/PMC3671487/ /pubmed/23728001 http://dx.doi.org/10.1038/ki.2013.94 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Knepper, Mark A.
Miranda, Carlos A.
Urea channel inhibitors (UCIs): A new functional class of aquaretics
title Urea channel inhibitors (UCIs): A new functional class of aquaretics
title_full Urea channel inhibitors (UCIs): A new functional class of aquaretics
title_fullStr Urea channel inhibitors (UCIs): A new functional class of aquaretics
title_full_unstemmed Urea channel inhibitors (UCIs): A new functional class of aquaretics
title_short Urea channel inhibitors (UCIs): A new functional class of aquaretics
title_sort urea channel inhibitors (ucis): a new functional class of aquaretics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671487/
https://www.ncbi.nlm.nih.gov/pubmed/23728001
http://dx.doi.org/10.1038/ki.2013.94
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