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Urea channel inhibitors (UCIs): A new functional class of aquaretics
Using large-scale small molecule screening techniques, Li et al. have identified a compound that inhibits the UT-B urea channel. They propose that this or similar compounds could be used as aquaretic agents to increase water excretion without changes in electrolyte excretion. Such compounds would po...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671487/ https://www.ncbi.nlm.nih.gov/pubmed/23728001 http://dx.doi.org/10.1038/ki.2013.94 |
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author | Knepper, Mark A. Miranda, Carlos A. |
author_facet | Knepper, Mark A. Miranda, Carlos A. |
author_sort | Knepper, Mark A. |
collection | PubMed |
description | Using large-scale small molecule screening techniques, Li et al. have identified a compound that inhibits the UT-B urea channel. They propose that this or similar compounds could be used as aquaretic agents to increase water excretion without changes in electrolyte excretion. Such compounds would potentially be useful in treatment of hyponatremic disorders. Here we review the physiological basis for the action of urea channel inhibitors in the kidney and assess their clinical potential. |
format | Online Article Text |
id | pubmed-3671487 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
record_format | MEDLINE/PubMed |
spelling | pubmed-36714872013-12-01 Urea channel inhibitors (UCIs): A new functional class of aquaretics Knepper, Mark A. Miranda, Carlos A. Kidney Int Article Using large-scale small molecule screening techniques, Li et al. have identified a compound that inhibits the UT-B urea channel. They propose that this or similar compounds could be used as aquaretic agents to increase water excretion without changes in electrolyte excretion. Such compounds would potentially be useful in treatment of hyponatremic disorders. Here we review the physiological basis for the action of urea channel inhibitors in the kidney and assess their clinical potential. 2013-06 /pmc/articles/PMC3671487/ /pubmed/23728001 http://dx.doi.org/10.1038/ki.2013.94 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Knepper, Mark A. Miranda, Carlos A. Urea channel inhibitors (UCIs): A new functional class of aquaretics |
title | Urea channel inhibitors (UCIs): A new functional class of aquaretics |
title_full | Urea channel inhibitors (UCIs): A new functional class of aquaretics |
title_fullStr | Urea channel inhibitors (UCIs): A new functional class of aquaretics |
title_full_unstemmed | Urea channel inhibitors (UCIs): A new functional class of aquaretics |
title_short | Urea channel inhibitors (UCIs): A new functional class of aquaretics |
title_sort | urea channel inhibitors (ucis): a new functional class of aquaretics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671487/ https://www.ncbi.nlm.nih.gov/pubmed/23728001 http://dx.doi.org/10.1038/ki.2013.94 |
work_keys_str_mv | AT kneppermarka ureachannelinhibitorsucisanewfunctionalclassofaquaretics AT mirandacarlosa ureachannelinhibitorsucisanewfunctionalclassofaquaretics |