For Better or Worse: A Niche for Notch in Parietal Epithelial Cell Activation

Podocyte (glomerular epithelial cell; GEC) dysfunction and loss are the hallmarks of focal segmental glomerulosclerosis (FSGS). Over the recent years, changes, including activation and proliferation of parietal epithelial cells (PEC) have been increasingly appreciated in FSGS. The functional role of...

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Detalles Bibliográficos
Autores principales: Sweetwyne, Mariya, Susztak, Katalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671494/
https://www.ncbi.nlm.nih.gov/pubmed/23728000
http://dx.doi.org/10.1038/ki.2013.66
Descripción
Sumario:Podocyte (glomerular epithelial cell; GEC) dysfunction and loss are the hallmarks of focal segmental glomerulosclerosis (FSGS). Over the recent years, changes, including activation and proliferation of parietal epithelial cells (PEC) have been increasingly appreciated in FSGS. The functional role of PECs in FSGS is still a hotly debated issue. Here Ueno et al. report that Notch signaling plays a role in orchestrating PEC cell phenotypic changes in FSGS.

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