For Better or Worse: A Niche for Notch in Parietal Epithelial Cell Activation

Podocyte (glomerular epithelial cell; GEC) dysfunction and loss are the hallmarks of focal segmental glomerulosclerosis (FSGS). Over the recent years, changes, including activation and proliferation of parietal epithelial cells (PEC) have been increasingly appreciated in FSGS. The functional role of...

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Detalles Bibliográficos
Autores principales: Sweetwyne, Mariya, Susztak, Katalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671494/
https://www.ncbi.nlm.nih.gov/pubmed/23728000
http://dx.doi.org/10.1038/ki.2013.66
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author Sweetwyne, Mariya
Susztak, Katalin
author_facet Sweetwyne, Mariya
Susztak, Katalin
author_sort Sweetwyne, Mariya
collection PubMed
description Podocyte (glomerular epithelial cell; GEC) dysfunction and loss are the hallmarks of focal segmental glomerulosclerosis (FSGS). Over the recent years, changes, including activation and proliferation of parietal epithelial cells (PEC) have been increasingly appreciated in FSGS. The functional role of PECs in FSGS is still a hotly debated issue. Here Ueno et al. report that Notch signaling plays a role in orchestrating PEC cell phenotypic changes in FSGS.
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spelling pubmed-36714942013-12-01 For Better or Worse: A Niche for Notch in Parietal Epithelial Cell Activation Sweetwyne, Mariya Susztak, Katalin Kidney Int Article Podocyte (glomerular epithelial cell; GEC) dysfunction and loss are the hallmarks of focal segmental glomerulosclerosis (FSGS). Over the recent years, changes, including activation and proliferation of parietal epithelial cells (PEC) have been increasingly appreciated in FSGS. The functional role of PECs in FSGS is still a hotly debated issue. Here Ueno et al. report that Notch signaling plays a role in orchestrating PEC cell phenotypic changes in FSGS. 2013-06 /pmc/articles/PMC3671494/ /pubmed/23728000 http://dx.doi.org/10.1038/ki.2013.66 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Sweetwyne, Mariya
Susztak, Katalin
For Better or Worse: A Niche for Notch in Parietal Epithelial Cell Activation
title For Better or Worse: A Niche for Notch in Parietal Epithelial Cell Activation
title_full For Better or Worse: A Niche for Notch in Parietal Epithelial Cell Activation
title_fullStr For Better or Worse: A Niche for Notch in Parietal Epithelial Cell Activation
title_full_unstemmed For Better or Worse: A Niche for Notch in Parietal Epithelial Cell Activation
title_short For Better or Worse: A Niche for Notch in Parietal Epithelial Cell Activation
title_sort for better or worse: a niche for notch in parietal epithelial cell activation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671494/
https://www.ncbi.nlm.nih.gov/pubmed/23728000
http://dx.doi.org/10.1038/ki.2013.66
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