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The Occurrence or Fibrillary Glomerulonephritis in Patients with Diabetes Mellitus May Not Be Coincidental: A Report of Four Cases

Although clinical presentation of fibrillary glomerulonephritis is similar to most forms of glomerulonephritis, it is usually difficult to make the diagnosis. Clinical manifestations include proteinuria, microscopic haematuria, nephrotic syndrome, and impairment of renal function. A diagnosis of fib...

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Detalles Bibliográficos
Autores principales: González-Cabrera, Fayna, Henríquez-Palop, Fernando, Ramírez-Puga, Ana, Santana-Estupiñán, Raquel, Plaza-Toledano, Celia, Antón-Pérez, Gloria, Marrero-Robayna, Silvia, Ramírez-Medina, Davinia, Gallego-Samper, Roberto, Vega-Díaz, Nicanor, Camacho-Galan, Rafael, Rodríguez-Pérez, José C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671515/
https://www.ncbi.nlm.nih.gov/pubmed/23762079
http://dx.doi.org/10.1155/2013/935172
Descripción
Sumario:Although clinical presentation of fibrillary glomerulonephritis is similar to most forms of glomerulonephritis, it is usually difficult to make the diagnosis. Clinical manifestations include proteinuria, microscopic haematuria, nephrotic syndrome, and impairment of renal function. A diagnosis of fibrillary glomerulonephritis is only confirmed by renal biopsy and it must comprise electronmicroscopy-verified ultrastructural findings. We report four cases between 45–50 years old with documented type 2 diabetes mellitus (T2DM) and arterial hypertension. All patients were found to have fibrils on kidney biopsy. The differential diagnosis of fibrils in the setting of diabetes mellitus is also discussed.