The Multifaceted Effects of Omega-3 Polyunsaturated Fatty Acids on the Hallmarks of Cancer

Omega-3 polyunsaturated fatty acids, in particular eicosapentaenoic acid, and docosahexaenoic acid have been shown to have multiple beneficial antitumour actions that affect the essential alterations that dictate malignant growth. In this review we explore the putative mechanisms of action of omega-...

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Autores principales: Stephenson, J. A., Al-Taan, O., Arshad, A., Morgan, B., Metcalfe, M. S., Dennison, A. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671553/
https://www.ncbi.nlm.nih.gov/pubmed/23762563
http://dx.doi.org/10.1155/2013/261247
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author Stephenson, J. A.
Al-Taan, O.
Arshad, A.
Morgan, B.
Metcalfe, M. S.
Dennison, A. R.
author_facet Stephenson, J. A.
Al-Taan, O.
Arshad, A.
Morgan, B.
Metcalfe, M. S.
Dennison, A. R.
author_sort Stephenson, J. A.
collection PubMed
description Omega-3 polyunsaturated fatty acids, in particular eicosapentaenoic acid, and docosahexaenoic acid have been shown to have multiple beneficial antitumour actions that affect the essential alterations that dictate malignant growth. In this review we explore the putative mechanisms of action of omega-3 polyunsaturated fatty acid in cancer protection in relation to self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion, and how these will hopefully translate from bench to bedside.
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spelling pubmed-36715532013-06-12 The Multifaceted Effects of Omega-3 Polyunsaturated Fatty Acids on the Hallmarks of Cancer Stephenson, J. A. Al-Taan, O. Arshad, A. Morgan, B. Metcalfe, M. S. Dennison, A. R. J Lipids Review Article Omega-3 polyunsaturated fatty acids, in particular eicosapentaenoic acid, and docosahexaenoic acid have been shown to have multiple beneficial antitumour actions that affect the essential alterations that dictate malignant growth. In this review we explore the putative mechanisms of action of omega-3 polyunsaturated fatty acid in cancer protection in relation to self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion, and how these will hopefully translate from bench to bedside. Hindawi Publishing Corporation 2013 2013-05-16 /pmc/articles/PMC3671553/ /pubmed/23762563 http://dx.doi.org/10.1155/2013/261247 Text en Copyright © 2013 J. A. Stephenson et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Stephenson, J. A.
Al-Taan, O.
Arshad, A.
Morgan, B.
Metcalfe, M. S.
Dennison, A. R.
The Multifaceted Effects of Omega-3 Polyunsaturated Fatty Acids on the Hallmarks of Cancer
title The Multifaceted Effects of Omega-3 Polyunsaturated Fatty Acids on the Hallmarks of Cancer
title_full The Multifaceted Effects of Omega-3 Polyunsaturated Fatty Acids on the Hallmarks of Cancer
title_fullStr The Multifaceted Effects of Omega-3 Polyunsaturated Fatty Acids on the Hallmarks of Cancer
title_full_unstemmed The Multifaceted Effects of Omega-3 Polyunsaturated Fatty Acids on the Hallmarks of Cancer
title_short The Multifaceted Effects of Omega-3 Polyunsaturated Fatty Acids on the Hallmarks of Cancer
title_sort multifaceted effects of omega-3 polyunsaturated fatty acids on the hallmarks of cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671553/
https://www.ncbi.nlm.nih.gov/pubmed/23762563
http://dx.doi.org/10.1155/2013/261247
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