Synergistic Effect of Lupenone and Caryophyllene Oxide against Trypanosoma cruzi

The in vitro trypanocidal activity of a 1 : 4 mixture of lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC(50) = 10.4 μg/mL, FIC = 0.46). In addition, testing of the terpenoid mixture for its capacity to reduce the number of...

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Detalles Bibliográficos
Autores principales: Polanco-Hernández, Glendy, Escalante-Erosa, Fabiola, García-Sosa, Karlina, Rosado, María E., Guzmán-Marín, Eugenia, Acosta-Viana, Karla Y., Giménez-Turba, Alberto, Salamanca, Efraín, Peña-Rodríguez, Luis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671683/
https://www.ncbi.nlm.nih.gov/pubmed/23762135
http://dx.doi.org/10.1155/2013/435398
Descripción
Sumario:The in vitro trypanocidal activity of a 1 : 4 mixture of lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC(50) = 10.4 μg/mL, FIC = 0.46). In addition, testing of the terpenoid mixture for its capacity to reduce the number of amastigote nests in cardiac tissue and skeletal muscle of infected mice showed a reduction of more than 80% at a dose level of 20.8 mg·kg(−1)·day(−1).

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