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Associations of plasma atrial natriuretic peptide and electrolyte levels with essential hypertension

This study aimed to investigate the associations among the levels of plasma atrial natriuretic peptide (ANP) and electrolytes and essential hypertension (EH) in Uygur, Han and Kazakh populations in Xinjiang. A total of 724 hypertensive participants of different ethnicities from Xinjiang (208 Uygur,...

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Autores principales: HU, GUANGMEI, XU, XINJUAN, LIANG, XIAOHUI, YANG, XIAOPING, ZHANG, JUNSHI, SIMAYI, ZHULEPIYA, CHEN, YULAN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671822/
https://www.ncbi.nlm.nih.gov/pubmed/23737895
http://dx.doi.org/10.3892/etm.2013.991
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author HU, GUANGMEI
XU, XINJUAN
LIANG, XIAOHUI
YANG, XIAOPING
ZHANG, JUNSHI
SIMAYI, ZHULEPIYA
CHEN, YULAN
author_facet HU, GUANGMEI
XU, XINJUAN
LIANG, XIAOHUI
YANG, XIAOPING
ZHANG, JUNSHI
SIMAYI, ZHULEPIYA
CHEN, YULAN
author_sort HU, GUANGMEI
collection PubMed
description This study aimed to investigate the associations among the levels of plasma atrial natriuretic peptide (ANP) and electrolytes and essential hypertension (EH) in Uygur, Han and Kazakh populations in Xinjiang. A total of 724 hypertensive participants of different ethnicities from Xinjiang (208 Uygur, 287 Han and 229 Kazakh) and 741 normal controls (208 Uygur, 267 Han and 266 Kazakh) were enrolled. The associations of ANP with serum potassium, serum sodium and blood pressure were assessed. In the normal control (NT) group, the concentration of ANP was higher in the Uygur population than in the Han population, and the concentration in the Han population was higher than that in the Kazakh population (P<0.05). In the EH group, the serum potassium levels of the Uygur and Han populations were higher than that of the Kazakh population (P<0.05). The ANP concentration in the Uygur ethnic group was higher than that in the Han population, which was in turn higher than that in the Kazakh participants (P<0.05). In the Kazakh population, the serum potassium level was significantly lower in the EH group compared with that in the NT group (P<0.05). The serum potassium level was significantly lower and the ANP concentration significantly higher in the EH group compared with those of NT groups in the Uygur and Han populations (P<0.05). Age and body mass index (BMI) were associated with hypertension in the Uygur, Han and Kazakh populations. Low serum potassium may be a risk factor of hypertension in individuals of Uygur and Kazakh ethnicity. Plasma ANP may be a regulatory factor involved in the development of hypertension in Uygur and Han populations.
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spelling pubmed-36718222013-06-04 Associations of plasma atrial natriuretic peptide and electrolyte levels with essential hypertension HU, GUANGMEI XU, XINJUAN LIANG, XIAOHUI YANG, XIAOPING ZHANG, JUNSHI SIMAYI, ZHULEPIYA CHEN, YULAN Exp Ther Med Articles This study aimed to investigate the associations among the levels of plasma atrial natriuretic peptide (ANP) and electrolytes and essential hypertension (EH) in Uygur, Han and Kazakh populations in Xinjiang. A total of 724 hypertensive participants of different ethnicities from Xinjiang (208 Uygur, 287 Han and 229 Kazakh) and 741 normal controls (208 Uygur, 267 Han and 266 Kazakh) were enrolled. The associations of ANP with serum potassium, serum sodium and blood pressure were assessed. In the normal control (NT) group, the concentration of ANP was higher in the Uygur population than in the Han population, and the concentration in the Han population was higher than that in the Kazakh population (P<0.05). In the EH group, the serum potassium levels of the Uygur and Han populations were higher than that of the Kazakh population (P<0.05). The ANP concentration in the Uygur ethnic group was higher than that in the Han population, which was in turn higher than that in the Kazakh participants (P<0.05). In the Kazakh population, the serum potassium level was significantly lower in the EH group compared with that in the NT group (P<0.05). The serum potassium level was significantly lower and the ANP concentration significantly higher in the EH group compared with those of NT groups in the Uygur and Han populations (P<0.05). Age and body mass index (BMI) were associated with hypertension in the Uygur, Han and Kazakh populations. Low serum potassium may be a risk factor of hypertension in individuals of Uygur and Kazakh ethnicity. Plasma ANP may be a regulatory factor involved in the development of hypertension in Uygur and Han populations. D.A. Spandidos 2013-05 2013-03-06 /pmc/articles/PMC3671822/ /pubmed/23737895 http://dx.doi.org/10.3892/etm.2013.991 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
HU, GUANGMEI
XU, XINJUAN
LIANG, XIAOHUI
YANG, XIAOPING
ZHANG, JUNSHI
SIMAYI, ZHULEPIYA
CHEN, YULAN
Associations of plasma atrial natriuretic peptide and electrolyte levels with essential hypertension
title Associations of plasma atrial natriuretic peptide and electrolyte levels with essential hypertension
title_full Associations of plasma atrial natriuretic peptide and electrolyte levels with essential hypertension
title_fullStr Associations of plasma atrial natriuretic peptide and electrolyte levels with essential hypertension
title_full_unstemmed Associations of plasma atrial natriuretic peptide and electrolyte levels with essential hypertension
title_short Associations of plasma atrial natriuretic peptide and electrolyte levels with essential hypertension
title_sort associations of plasma atrial natriuretic peptide and electrolyte levels with essential hypertension
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671822/
https://www.ncbi.nlm.nih.gov/pubmed/23737895
http://dx.doi.org/10.3892/etm.2013.991
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